Anti-CD155 / PVR Antibody (PerCP)

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Anti-CD155 / PVR Antibody (PerCP) (Rabbit Monoclonal 抗体) 产品信息

产品名称
Anti-CD155 / PVR Antibody (PerCP)
经验证的应用
FCM
交叉反应
Reacts with: Mouse
特异性
Mouse CD155 / PVR
免疫原
Recombinant Mouse CD155 protein (Catalog#50259-M08H)
制备方法
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD155 / PVR (rM CD155 / PVR; Catalog#50259-M08H; NP_081790.1; Met 1-Arg 345) and conjugated with PerCP under optimum conditions, the unreacted PerCP was removed.
来源
Monoclonal Rabbit IgG Clone #305
纯化
Protein A
缓冲液
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
偶联物
PerCP
浓度
10 μl/Test, 0.1 mg/ml
状态
Liquid
运输方式
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
储存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-CD155 / PVR Antibody (PerCP) (Rabbit Monoclonal 抗体) 图片

Flow cytometric analysis of PVR (CD155) expression on Raw264.7 cells. Cells were treated with Mouse BD Fc Block™ purified anti-CD16/CD32 mAb 2.4G2 (Cat. No. 553141) and stained with PerCP-conjugated anti-Mouse PVR (50259-R305-C). The histogram were derived from the gated events based on light scattering characteristics of intact cells.

Anti-CD155 / PVR Antibody (PerCP): 别称

Anti-3830421F03Rik Antibody; Anti-CD155 Antibody; Anti-D7Ertd458e Antibody; Anti-HVED Antibody; Anti-mE4 Antibody; Anti-necl-5 Antibody; Anti-PVS Antibody; Anti-Taa1 Antibody; Anti-Tage4 Antibody

CD155 / PVR 背景信息

CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.
全称
poliovirus receptor
参考文献
  • Freistadt MS, et al. (2000) Hematopoietic cells from CD155-transgenic mice express CD155 and support poliovirus replication ex vivo. Microb Pathog. 29(4): 203-12.
  • Sato T, et al. (2004) Involvement of heterophilic trans-interaction of Necl-5/Tage4/PVR/CD155 with nectin-3 in formation of nectin- and cadherin-based adherens junctions. Genes Cells. 9(9): 791-9.
  • Kakunaga S, et al. (2004) Enhancement of serum- and platelet-derived growth factor-induced cell proliferation by Necl-5/Tage4/poliovirus receptor/CD155 through the Ras-Raf-MEK-ERK signaling. J Biol Chem. 279(35): 36419-25.
  • Sato T, et al. (2005) Common signaling pathway is used by the trans-interaction of Necl-5/Tage4/PVR/CD155 and nectin, and of nectin and nectin during the formation of cell-cell adhesion. Cancer Sci. 96(9): 578-89.
  • Minami Y, et al. (2007) Involvement of up-regulated Necl-5/Tage4/PVR/CD155 in the loss of contact inhibition in transformed NIH3T3 cells. Biochem Biophys Res Commun. 352(4): 856-60.
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