L1CAM Matched ELISA Antibody Pair Set,Human

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L1CAM Matched ELISA Antibody Pair Set,Human 产品信息

产品名称
L1CAM Matched ELISA Antibody Pair Set,Human
检测原理
Solid Phase Sandwich ELISA
特异性
Quantitative determination of Human L1CAM
线性范围
46.88-3000 pg/mL
ELISA 抗体对套装(非即用型)组分
1. Capture Antibody 1.0 mg/mL of rabbit anti-CD171 monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in CBS before coating. (Catalog: # 10140-R001)
2. Detection Antibody 0.5 mg/mL rabbit anti-CD171 monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % glycerol, pH 7.4). Dilute to working concentration of 0.5 μg/mL in detection antibody dilution buffer before use. (Catalog: # 10140-R014)
3. Standard Each vial contains 39 ng of recombinant CD171. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 3 ng/mL is recommended.
产品概述
This L1CAM Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human L1CAM . It contains Human L1CAM capture antibody, Human L1CAM detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human L1CAM protein. This Pair Set is at affordable price for researchers.
运输方式
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
储存条件
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Protect it from prolonged exposure to light. Aliquot and store at -20℃ to -80℃ and for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

L1CAM Matched ELISA Antibody Pair Set,Human 图片

L1CAM Matched ELISA Antibody Pair Set,Human: 别称

CAML1 Matched ELISA Antibody Pair Set, Human; CD171 Matched ELISA Antibody Pair Set, Human; HSAS Matched ELISA Antibody Pair Set, Human; HSAS1 Matched ELISA Antibody Pair Set, Human; MASA Matched ELISA Antibody Pair Set, Human; MIC5 Matched ELISA Antibody Pair Set, Human; N-CAM-L1 Matched ELISA Antibody Pair Set, Human; N-CAML1 Matched ELISA Antibody Pair Set, Human; NCAM-L1 Matched ELISA Antibody Pair Set, Human; S10 Matched ELISA Antibody Pair Set, Human; SPG1 Matched ELISA Antibody Pair Set, Human

L1CAM 背景信息

L1 cell adhesion molecule (L1CAM), also designated as CD171, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and in a variety of cancer cells, including some common types of human cancer. L1CAM interacts with a variety of ligands including axonin-1, CD9, neurocan and intergrins, and it has been revealed that the RGD motif in the sixth Ig domain of L1CAM is a binding site for integrins, thus important for nuclear signaling. Disruption of L1CAM function causes three X-linked neurological syndromes, i.e. hydrocephalus, MASA syndrome (mental retardation, aphasia, shuffling gait and adducted thumbs) and spastic paraplegia syndrome. Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate and promoted cell transformation and tumorigenicity. Recent work has identified L1CAM (CD171) as a novel marker for human carcinoma progression, and a candidate for anti-cancer therapy.
全称
L1 cell adhesion molecule
参考文献
  • Meier F, et al. (2006) The adhesion molecule L1 (CD171) promotes melanoma progression. Int J Cancer. 119(3): 549-55.
  • Gavert N, et al. (2008) L1-CAM in cancerous tissues. Expert Opin Biol Ther. 8(11): 1749-57.
  • Issa Y, et al. (2009) Enhanced L1CAM expression on pancreatic tumor endothelium mediates selective tumor cell transmigration. J Mol Med. 87(1): 99-112.
  • Weidle UH, et al. (2009) L1-CAM as a target for treatment of cancer with monoclonal antibodies. Anticancer Res. 29(12): 4919-31.
  • Raveh S, et al. (2009) L1 cell adhesion molecule (L1CAM) in invasive tumors. Cancer Lett. 282(2): 137-45.
  • Wolterink S, et al. (2010) Therapeutic antibodies to human L1CAM: functional characterization and application in a mouse model for ovarian carcinoma. Cancer Res. 70(6): 2504-15.
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