CD36 Protein, Human, Recombinant (His Tag)

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CD36 Protein, Human, Recombinant (His Tag): 产品信息

纯度
> 88 % as determined by SDS-PAGE
内毒素
< 1.0 EU per μg of the protein as determined by the LAL method
生物活性
Testing in progress
蛋白构建
A DNA sequence encoding the human CD36 (NP_001001547.1) extracellular domain (Gly 30-Asn 439) was fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus.
表达宿主
HEK293 Cells
种属
Human
预测 N 端
Asp 31
分子量
The secreted recombinant human CD36 comprises 420 amino acids with a predicted molecular mass of 48 kDa. As a result of glycosylation, the apparent molecular mass of rh CD36 is approximately 70-80 kDa in SDS-PAGE under reducing conditions.
缓冲液
Lyophilized from sterile PBS, pH 7.4
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
运输方式
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
稳定性 & 储存条件
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
复溶
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CD36 Protein, Human, Recombinant (His Tag): 图片

CD36 Protein, Human, Recombinant (His Tag): 别称

BDPLT10 Protein, Human; CHDS7 Protein, Human; FAT Protein, Human; GP3B Protein, Human; GP4 Protein, Human; GPIV Protein, Human; PASIV Protein, Human; SCARB3 Protein, Human

CD36 背景信息

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 32 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 36 (CD36), also known as FAT, SCARB3, GP88, glycoprotein IV (gpIV) and glycoprotein IIIb (gpIIIb), is a member of the CD system as well as the class B scavenger receptor family of cell surface proteins. CD36 can be found on the surface of many cell types in vertebrate animals and it consists of 472 amino acids and is extensively glycosylated. It is an integral membrane protein primarily serving as receptors for thrombospondin and collagen and by the erythrocytes infected with the human malaria parasite. The role of CD36 as a cell surface receptor has been extended to that of a signal transduction molecule.
全称
CD36 molecule (thrombospondin receptor)
研究领域
参考文献
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Greenwalt RH, et al. (1992) Membrane glycoprotein in CD36: a review of its roles in adherence, signal transduction, and transfusion medicine. The journal of the American society of hematology. 80 (5): 1105-15.
  • Probing the cytoadherence of malaria infected red blood cells under flow
    Author
    Xu, X;Efremov, AK;Li, A;Lai, L;Dao, M;Lim, CT;Cao, J;
    Year
    2013
    Journal
    PLoS ONE
    Application
    adhesion experiments
  • Insights into binding of S100 proteins to scavenger receptors: class B scavenger receptor CD36 binds S100A12 with high affinity
    Author
    Tondera, C;Laube, M;Pietzsch, J;
    Year
    2016
    Journal
    Amino Acids
    Application
    SPR
  • Polymer brain-nanotherapeutics for multipronged inhibition of microglial α-synuclein aggregation, activation, and neurotoxicity
    Author
    Bennett, NK;Chmielowski, R;Abdelhamid, DS;Faig, JJ;Francis, N;Baum, J;Pang, ZP;Uhrich, KE;Moghe, PV;
    Year
    2016
    Journal
    Biomaterials
    Application
    binding (pull-down)
  • All three human scavenger receptor class B proteins can bind and transport all three macular xanthophyll carotenoids.
    Author
    Shyam, R;Vachali, P;Gorusupudi, A;Nelson, K;Bernstein, PS;
    Year
    2017
    Journal
    Arch. Biochem. Biophys.
  • Single molecule and multiple bond characterization of catch bond associated cytoadhesion in malaria
    Author
    Lim, YB;Thingna, J;Cao, J;Lim, CT;
    Year
    2017
    Journal
    Sci Rep
  • Analysis of exported proteins and parasite-induced host cell rigidity changes during the Plasmodium falciparum intraerythrocxytic life cycle
    Author
    Schibler, B;
    Year
    2018
    Journal
    Thesis
    Application
    binding
  • Fatty acid-induced CD36 expression via O-GlcNAcylation drives gastric cancer metastasis
    Author
    Jiang, M;Wu, N;Xu, B;Chu, Y;Li, X;Su, S;Chen, D;Li, W;Shi, Y;Gao, X;Zhang, H;Zhang, Z;Du, W;Nie, Y;Liang, J;Fan, D;
    Year
    2019
    Journal
    Theranostics
    Application
    substrate
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