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ACVR1 cDNA ORF Clone, Mouse, N-HA tag

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ACVR1 cDNA ORF Clone, Mouse, N-HA tag: 产品信息

基因
种属
Mouse
NCBI 参考序列号
基因长度
1530 bp
序列特征
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 327G/A and 1014 A/G not causing the amino acid variation.
产品特征
Full length Clone DNA of Mouse activin A receptor, type 1 with N terminal HA tag.
质粒
启动子
Enhanced CMV promoter
载体
限制性酶切位点
HindIII + XbaI (6kb + 1.62kb)
标签序列
HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Kanamycin
细胞筛选抗性
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

ACVR1 cDNA ORF 核苷酸序列及氨基酸序列信息

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

ACVR1 cDNA ORF Clone, Mouse, N-HA tag: 验证图片

ACVR1 cDNA ORF Clone, Mouse, N-HA tag: 别称

ActR-I cDNA ORF Clone, Mouse; ActRIA cDNA ORF Clone, Mouse; Acvr cDNA ORF Clone, Mouse; Acvrlk2 cDNA ORF Clone, Mouse; Alk-2 cDNA ORF Clone, Mouse; ALK2 cDNA ORF Clone, Mouse; Alk8 cDNA ORF Clone, Mouse; D330013D15Rik cDNA ORF Clone, Mouse; SKR1 cDNA ORF Clone, Mouse; Tsk7L cDNA ORF Clone, Mouse

ACVR1 背景信息

ALK-2, also termed as ACVR1, was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been demonstrated that ALK-2 forms complex with either the BMP-2/7-bound BMPR-II or ACVR2A /ACVR2B. ALK-1 and ALK-2 presenting in the yeast Saccharomyces cerevisiae are two haspin homologues. Both ALK-1 and ALK-2 exhibit a weak auto-kinase activity in vitro, and are phosphoproteins in vivo. ALK-1 and ALK-2 levels peak in mitosis and late-S/G2. Control of protein stability plays a major role in ALK-2 regulation. The half-life of ALK-2 is particularly short in G1. Overexpression of ALK-2, but not of ALK-1, causes a mitotic arrest, which is correlated to the kinase activity of the protein. This suggests a role for ALK-2 in the control of mitosis. Endoglin is phosphorylated on cytosolic domain threonine residues by the TGF-beta type I receptors ALK-2 and ALK-5 in prostate cancer cells. Endoglin did not inhibit cell migration in the presence of constitutively active ALK-2. Defects in ALK-2 are a cause of fibrodysplasia ossificans progressiva (FOP).
全称
activin A receptor, type I
参考文献
  • Armes NA,et al. (1997) The ALK-2 and ALK-4 activin receptors transduce distinct mesoderm-inducing signals during early Xenopus development but do not co-operate to establish thresholds. Development 124(19): 3797-804.
  • Armes NA, et al. (1999) A short loop on the ALK-2 and ALK-4 activin receptors regulates signaling specificity but cannot account for all their effects on early Xenopus development. J Biol Chem. 274(12):7929-35.
  • Kawai S, et al. (2000) Mouse smad8 phosphorylation downstream of BMP receptors ALK-2, ALK-3, and ALK-6 induces its association with Smad4 and transcriptional activity.Biochem Biophys Res Commun. 271(3):682-7.
  • Deng Y, et al. (2009) Efficient highly selective synthesis of methyl 2-(ethynyl)alk-2(E)-enoates and 2-(1'-chlorovinyl)alk-2(Z)-enoates from 2-(methoxycarbonyl)-2,3-allenols. Organic letters 11(10):2169-72.

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