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ALK4/ACVR1B cDNA ORF Clone, Mouse, C-His tag

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ALK4/ACVR1B cDNA ORF Clone, Mouse, C-His tag: 产品信息

基因
种属
Mouse
NCBI 参考序列号
基因长度
1518 bp
产品特征
Full length Clone DNA of Mouse activin A receptor, type 1B with C terminal His tag.
质粒
启动子
Enhanced CMV promoter
载体
标签序列
His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
测序引物
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
质控
The plasmid is confirmed by full-length sequencing.
筛选
细菌筛选抗性
Kanamycin
细胞筛选抗性
Hygromycin
应用
Stable or Transient mammalian expression
储存 & 运输
运输方式
Each tube contains lyophilized plasmid.
储存条件
The lyophilized plasmid can be stored at ambient temperature for three months.

关于 ALK4/ACVR1B的更多信息

Entrez Gene ID

ALK4/ACVR1B cDNA ORF Clone, Mouse, C-His tag: 别称

6820432J04 cDNA ORF Clone, Mouse; ActR-IB cDNA ORF Clone, Mouse; ActRIB cDNA ORF Clone, Mouse; Acvrlk4 cDNA ORF Clone, Mouse; Alk4 cDNA ORF Clone, Mouse; SKR2 cDNA ORF Clone, Mouse

ALK4/ACVR1B 背景信息

ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.
全称
activin A receptor, type IB
参考文献
  • Chen Y, et al. (2005) Developmental analysis of activin-like kinase receptor-4 (ALK4) expression in Xenopus laevis. 232(2): 393-8.
  • J. Massagu. (1998) TGF- SIGNAL TRANSDUCTION. Annual Review of Biochemistry. 67: 753-91.
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