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人 Carbonic Anhydrase IX / CA9 蛋白 (His 标签)

产品数据评论实验方法
反应性: Human  
应用 : ELISA  FCM  
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10107-R036-50
10107-R036-100
50 µg 
100 µg 
Add to Cart
反应性: Human  
应用 : ELISA  IHC-P  
  • Slide 1
10107-RP02-50
10107-RP02-200
10107-RP02-100
50 µg 
200 µg 
100 µg 
Add to Cart
反应性: Human  
应用 : ELISA  IHC-P  
  • Slide 1
  • Slide 1
  • Slide 1
  • Slide 1
10107-R005-50
10107-R005-100
50 µg 
100 µg 
Add to Cart
反应性: Human  
应用 : 
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10107-T48-50
10107-T48-200
10107-T48-100
50 µg 
200 µg 
100 µg 
Add to Cart
反应性: Human  
应用 : ELISA  WB  IP  
  • Slide 1
  • Slide 1
10107-R003-50
10107-R003-100
50 µg 
100 µg 
Add to Cart
反应性: Human  
应用 : ELISA  
    10107-RP01-400
    10107-RP01-200
    10107-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    反应性: Mouse  
    应用 : ELISA  
      50660-RP01-400
      50660-RP01-200
      50660-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      反应性: Mouse  
      应用 : IHC-P  
      • Slide 1
      50660-R001-50
      50660-R001-100
      50 µg 
      100 µg 
      Add to Cart
      反应性: Mouse  
      应用 : ELISA  WB  IHC-P  
      • Slide 1
      • Slide 1
      • Slide 1
      50660-RP02-50
      50660-RP02-200
      50660-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      反应性: Canine  
      应用 : ELISA  WB  IP  
      • Slide 1
      • Slide 1
      70028-T52-50
      70028-T52-200
      70028-T52-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      反应性: Canine  
      应用 : ELISA  
        70028-RP01-400
        70028-RP01-200
        70028-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart

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        Carbonic Anhydrase IX/CA9 protein 研究背景

        Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3–) and thus participate in a variety of biological and physical processes. CA IX protein is expressed primarily in carcinoma cells lines, and the expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. It is involved in tumorigenesis through many pathways, such as pH regulation and cell adhesion control. CA IX is used as a marker of tumor hypoxia and as a new therapeutic target for many human carcinomas and cancers.

        Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

         Carbonic Anhydrase IX/CA9 protein 参考资料
      • Loncaster JA, et al. (2001) Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res. 61(17): 6394-9.
      • Zvada J, et al. (2003) Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients. Br J Cancer. 89(6): 1067-71.
      • Pan P, et al. (2006) Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice. J Physiol. 571(Pt 2): 319-27.
      • Zhou GX, et al. (2010) Quantification of carbonic anhydrase IX expression in serum and tissue of renal cell carcinoma patients using enzyme-linked immunosorbent assay: prognostic and diagnostic potentials. Urology. 75(2): 257-61.
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