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人 ACE2 / Angiotensin-Converting Enzyme 2 蛋白 (Fc 标签)

产品数据评论实验方法
反应性: Human  
应用 : ELISA  WB  IHC-P  
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10108-T56-50
10108-T56-200
10108-T56-100
50 µg 
200 µg 
100 µg 
Add to Cart
反应性: Human  
应用 : 
    10108-RP01-400
    10108-RP01-200
    10108-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    反应性: Rat  
    应用 : IHC-P  
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    80031-R039-50
    80031-R039-100
    50 µg 
    100 µg 
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    反应性: Rat  
    应用 : ELISA  
      80031-RP02-50
      80031-RP02-200
      80031-RP02-100
      50 µg 
      200 µg 
      100 µg 
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      反应性: Rat  
      应用 : 
        80031-R003-50
        80031-R003-100
        80031-R003-1
        50 µg 
        100 µg 
        1 mg 
        Add to Cart
        反应性: Rat  
        应用 : 
          80031-MM04-50
          80031-MM04-200
          80031-MM04-100
          80031-MM04-1
          50 µg 
          200 µg 
          100 µg 
          1 mg 
          Add to Cart
          反应性: Rat  
          应用 : ELISA  
            80031-R001-50
            80031-R001-100
            50 µg 
            100 µg 
            Add to Cart
            反应性: Rat  
            应用 : ELISA  
              80031-RP01-400
              80031-RP01-200
              80031-RP01-100
              400 µg 
              200 µg 
              100 µg 
              Add to Cart

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              ACE2 / Angiotensin-Converting Enzyme 2 protein 研究背景

              Angiotensin-converting enzyme 2 (ACE2), a first homolog of ACE, regulates the renin angiotensin system (RAS) by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems. ACE2 also has an important role in blood pressure control. This enzyme, an homolog of ACE, hydrolyzes angiotensin (Ang) I to produce Ang-(1-9), which is subsequently converted into Ang-(1-7) by a neutral endopeptidase and ACE. ACE2 releases Ang-(1-7) more efficiently than its catalysis of Ang-(1-9) by cleavage of Pro(7)-Phe(8) bound in Ang II. Thus, the major biologically active product of ACE2 is Ang-(1-7), which is considered to be a beneficial peptide of the RAS cascade in the cardiovascular system. A physiological role for ACE2 has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the severe acute respiratory syndrome coronavirus. In the acute respiratory distress syndrome (ARDS), ACE, AngII, and AT1R promote the disease pathogenesis, whereas ACE2 and the AT2R protect from ARDS. Importantly, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in severe acute respiratory syndrome (SARS) pathogenesis. Furthermore, the recent explosion of research into the ACE2 homolog, collectrin, has revealed a new physiological function of ACE2 as an amino acid transporter, which explains the pathogenic role of gene mutations in Hartnup disorder. This review summarizes and discusses the recently unveiled roles for ACE2 in disease pathogenesis.

               ACE2 / Angiotensin-Converting Enzyme 2 protein 参考资料
            • Koitka A, et al. (2008) Angiotensin converting enzyme 2 in the kidney. Clin Exp Pharmacol Physiol. 35(4): 420-5.
            • Raizada MK, et al. (2007) ACE2: a new target for cardiovascular disease therapeutics. J Cardiovasc Pharmacol. 50(2): 112-9.
            • Imai Y, et al. (2007) Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circ J. 74(3): 405-10.
            • Turner AJ, et al. (2004) ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol Sci. 25(6): 291-4.
            • 请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”