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人 Cadherin-8 / CDH8 基因ORF全长cDNA克隆(表达载体), C-Flag 标签

产品数据评论实验方法
表达宿主: Human Cells  
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10144-H08H-5
10144-H08H-20
10144-H08H-10
5 µg 
20 µg 
10 µg 
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表达宿主: Human Cells  
  • Slide 1
80278-R08H-5
80278-R08H-10
5 µg 
10 µg 
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表达宿主: Human Cells  
  • Slide 1
80278-RCCH-5
80278-RCCH-20
80278-RCCH-10
5 µg 
20 µg 
10 µg 
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反应性: Human  
应用 : ELISA  
    10144-R032-50
    10144-R032-100
    50 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  
      10144-T16-50
      10144-T16-200
      10144-T16-100
      50 µg 
      200 µg 
      100 µg 
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      反应性: Human  
      应用 : ELISA  
        10144-RP01-400
        10144-RP01-200
        10144-RP01-100
        400 µg 
        200 µg 
        100 µg 
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        Cadherin-8 / CDH8 cdna-clone 研究背景

        Cadherins are integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Type I cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of five subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I  cadherins. Cadherin 8, also known as CDH 8, is a type I I classical cadherin belonging to the cadherin superfamily. As mainly expressed in brain, CDH8 is found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts, and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Human Cadherin 8 is a 799 amino acid single-pass type I  transmembrane protein with a putative 29 aa signal sequence, and a 32 aa propeptide, a 560 aa mature extracellular domain, a 21 aa transmembrane domain and a 157 aa cytoplasmic domain. The human, mouse and rat proteins share approximately 98% homology.

         Cadherin-8 / CDH8 cdna-clone 参考资料
      • Tanihara, H. et al., 1994, Cell Adhes. Comm. 2:15-26.
      • Kido, M. et al., 1998, Genomics 48:186-194.
      • Yamagata, K. et al., 1999, J. Biol. Chem. 274:19473-19479.
      • Nollet, F. et al., 2000, J. Mol. Biol. 299:551-572.
      • Blaschke, S. et al., 2002, Int. J. Cancer. 101 (4): 327-334.
      • Strausberg,R.L. et al., 2003, Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903.
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