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人 IL1R2 / IL1RB / CD121b 蛋白 (His 标签)

产品数据评论实验方法
反应性: Human  
应用 : 
    10111-R041-50
    10111-R041-100
    10111-R041-1
    50 µg 
    100 µg 
    1 mg 
    Add to Cart
    反应性: Human  
    应用 : ELISA  
      10111-RP01-400
      10111-RP01-200
      10111-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      反应性: Human  
      应用 : 
        10111-MM02-50
        10111-MM02-200
        10111-MM02-100
        10111-MM02-1
        50 µg 
        200 µg 
        100 µg 
        1 mg 
        Add to Cart
        反应性: Human  
        应用 : ELISA  
          10111-MM11-50
          10111-MM11-200
          10111-MM11-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          反应性: Human  
          应用 : ELISA  
            10111-R020-50
            10111-R020-100
            50 µg 
            100 µg 
            Add to Cart
            反应性: Human  
            应用 : ELISA  
              10111-MM04-50
              10111-MM04-200
              10111-MM04-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart
              反应性: Human  
              应用 : ELISA  
                10111-RP02-50
                10111-RP02-200
                10111-RP02-100
                50 µg 
                200 µg 
                100 µg 
                Add to Cart
                反应性: Mouse  
                应用 : ELISA  
                  51090-RP01-400
                  51090-RP01-200
                  51090-RP01-100
                  400 µg 
                  200 µg 
                  100 µg 
                  Add to Cart
                  反应性: Mouse  
                  应用 : ELISA  
                    51090-T16-50
                    51090-T16-200
                    51090-T16-100
                    50 µg 
                    200 µg 
                    100 µg 
                    Add to Cart
                    反应性: Rat  
                    应用 : ELISA  
                      80196-MM05-50
                      80196-MM05-200
                      80196-MM05-100
                      80196-MM05-1
                      50 µg 
                      200 µg 
                      100 µg 
                      1 mg 
                      Add to Cart
                      反应性: Rat  
                      应用 : 
                        80196-R161-50
                        80196-R161-100
                        80196-R161-1
                        50 µg 
                        100 µg 
                        1 mg 
                        Add to Cart
                        反应性: Rat  
                        应用 : ELISA  
                          80196-RP01-400
                          80196-RP01-200
                          80196-RP01-100
                          400 µg 
                          200 µg 
                          100 µg 
                          Add to Cart
                          反应性: Rat  
                          应用 : ELISA  
                            80196-R021-50
                            80196-R021-100
                            50 µg 
                            100 µg 
                            Add to Cart

                            IL-1R2/CD121b ELISA配对抗体

                            检测限:
                            SEK80196-5
                            SEK80196-15
                            5 Plates 
                            15 Plates 
                            Add to Cart
                            检测限: 9.375 pg/ml
                            SEK10111-5
                            SEK10111-15
                            5 Plates 
                            15 Plates 
                            Add to Cart

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                            IL-1R2/CD121b protein 研究背景

                            Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.

                             IL-1R2/CD121b protein 参考资料
                          • Cannon JG, et al. (1997) Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. J Clin Immunol. 17 (3): 253-61.
                          • Liu C, et al. (1996) Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J Biol Chem. 271 (34): 20965-72.
                          • Van der Poll T, et al. (1997) Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Infect Dis. 175 (1): 118-22.
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