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IL1R2 / IL1RB / CD121b 抗体, 兔单抗

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描述: Active  
表达宿主: Human Cells  
  • Slide 1
10111-H02H-50
10111-H02H-100
50 µg 
100 µg 
Add to Cart
描述: Active  
表达宿主: Human Cells  
  • Slide 1
10111-H08H-50
10111-H08H-100
50 µg 
100 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
10111-HCCH-50
10111-HCCH-100
50 µg 
100 µg 
Add to Cart
描述: Active  
表达宿主: Human Cells  
  • Slide 1
51090-M02H-50
51090-M02H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
51090-M08H-200
51090-M08H-100
200 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
80196-R08H-50
80196-R08H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
90120-C02H-50
90120-C02H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
70093-D02H-50
70093-D02H-20
50 µg 
20 µg 
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IL-1R2/CD121b ELISA配对抗体

检测限:
SEK80196-5
SEK80196-15
5 Plates 
15 Plates 
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检测限: 9.375 pg/ml
SEK10111-5
SEK10111-15
5 Plates 
15 Plates 
Add to Cart

IL-1R2/CD121b 抗体Related Products

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IL-1R2/CD121b antibody 研究背景

Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.

 IL-1R2/CD121b antibody 参考资料
  • Cannon JG, et al. (1997) Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. J Clin Immunol. 17 (3): 253-61.
  • Liu C, et al. (1996) Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J Biol Chem. 271 (34): 20965-72.
  • Van der Poll T, et al. (1997) Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Infect Dis. 175 (1): 118-22.
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