Text Size:AAA

人 VCAM-1 / CD106 蛋白 (His 标签)

产品数据评论实验方法
反应性: Human  
应用 : ELISA  
    10113-RP01-400
    10113-RP01-200
    10113-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    反应性: Human  
    应用 : WB  
    • Slide 1
    10113-T32-50
    10113-T32-200
    10113-T32-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    反应性: Human  
    应用 : 
    • Slide 1
    • Slide 1
    • Slide 1
    100507-T38-50
    100507-T38-200
    100507-T38-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    反应性: Mouse  
    应用 : 
      50163-T16-50
      50163-T16-200
      50163-T16-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      反应性: Mouse  
      应用 : ELISA  
        50163-RP01-400
        50163-RP01-200
        50163-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart
        反应性: Mouse  
        应用 : ELISA  
          50163-R130-50
          50163-R130-100
          50 µg 
          100 µg 
          Add to Cart
          反应性: Mouse  
          应用 : ELISA  
            50163-R119-50
            50163-R119-100
            50 µg 
            100 µg 
            Add to Cart
            反应性: Mouse  
            应用 : ELISA  
              50163-RP02-50
              50163-RP02-200
              50163-RP02-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart

              VCAM1/VCAM-1/CD106 蛋白Related Products

              Related Products

              Featured Reagent Products

              VCAM1/VCAM-1/CD106 protein 研究背景

              Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM-1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM-1 is an endothelial ligand for very late antigen-4 (VLA-4) and α4ß7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.

              Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

               VCAM1/VCAM-1/CD106 protein 参考资料
            • Cook-Mills JM. (2002) VCAM-1 signals during lymphocyte migration: role of reactive oxygen species. Mol Immunol. 39(9): 499-508.
            • Preiss DJ, et al. (2007) Vascular cell adhesion molecule-1: a viable therapeutic target for atherosclerosis? Int J Clin Pract. 61(4): 697-701.
            • 请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”