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人 CD146 / MCAM 蛋白 (His 标签)

产品数据评论实验方法
反应性: Human  
应用 : FCM  
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10115-MM01-P-25
10115-MM01-P-100
25 Test 
100 Tests 
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反应性: Human  
应用 : FCM  
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10115-MM01-A-25
10115-MM01-A-100
25 Test 
100 Tests 
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反应性: Human  
应用 : FCM  
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10115-R044-A-25
10115-R044-A-100
25 Test 
100 Tests 
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反应性: Human  
应用 : ELISA  IHC-P  
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10115-RP02-50
10115-RP02-200
10115-RP02-100
50 µg 
200 µg 
100 µg 
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反应性: Human  
应用 : WB  IHC-P  IP  
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10115-R005-50
10115-R005-100
50 µg 
100 µg 
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反应性: Human  
应用 : ELISA  IHC-P  FCM  IF  ICC/IF  
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10115-R044-50
10115-R044-100
10115-R044-1
50 µg 
100 µg 
1 mg 
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反应性: Human  
应用 : ELISA  IP  
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10115-MM05-50
10115-MM05-200
10115-MM05-100
10115-MM05-1
50 µg 
200 µg 
100 µg 
1 mg 
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反应性: Human  
应用 : FCM  
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10115-MM01-50
10115-MM01-200
10115-MM01-100
50 µg 
200 µg 
100 µg 
Add to Cart
反应性: Human  
应用 : ELISA  
    10115-MM04-50
    10115-MM04-200
    10115-MM04-100
    50 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : FCM  IF  ICC/IF  
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    10115-R044-F-25
    10115-R044-F-100
    25 Test 
    100 Tests 
    Add to Cart
    反应性: Human  
    应用 : ELISA  
      10115-RP01-400
      10115-RP01-200
      10115-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      反应性: Human  
      应用 : ELISA  WB  IHC-P  
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      10115-R012-50
      10115-R012-100
      50 µg 
      100 µg 
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      反应性: Human  
      应用 : FCM  IF  ICC/IF  
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      10115-R044-P-25
      10115-R044-P-100
      25 Test 
      100 Tests 
      Add to Cart
      反应性: Mouse  
      应用 : ELISA  
        50794-RP01-400
        50794-RP01-200
        50794-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart
        反应性: Mouse  
        应用 : ELISA  WB  IHC-P  IP  
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        50794-RP02-50
        50794-RP02-200
        50794-RP02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        反应性: Mouse  
        应用 : ELISA  
          50794-R112-50
          50794-R112-100
          50 µg 
          100 µg 
          Add to Cart

          CD146/MCAM 蛋白Related Products

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          CD146/MCAM protein 研究背景

          The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body, and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumours, and thus has been suggested to play an important role in tumour progression and the development of metastasis in certain human carcinomas.

           CD146/MCAM protein 参考资料
        • Mills L, et al. (2002) Fully human antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma. Cancer Res. 62(17): 5106-14.
        • Taira E, et al. (2004) Characterization of Gicerin/MUC18/CD146 in the rat nervous system. J Cell Physiol. 198(3): 377-87.
        • Fritzsche FR, et al. (2008) CD146 protein in prostate cancer: revisited with two different antibodies. Pathology. 40(5): 457-64.
        • Bidlingmaier S, et al. (2009) Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Cancer Res. 69(4): 1570-7.
        • Boneberg EM, et al. (2009) Soluble CD146 is generated by ectodomain shedding of membrane CD146 in a calcium-induced, matrix metalloprotease-dependent process. Microvasc Res. 78(3): 325-31.
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