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IL-18 抗体, 兔单抗

产品数据评论实验方法
表达宿主: E. coli  
  • Slide 1
10119-HNCE-5
10119-HNCE-20
10119-HNCE-100
5 µg 
20 µg 
100 µg 
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表达宿主: E. coli  
  • Slide 1
10119-H09E-50
10119-H09E-20
50 µg 
20 µg 
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表达宿主: E. coli  
  • Slide 1
50073-MNCE-50
50073-MNCE-20
50 µg 
20 µg 
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描述: Active  
表达宿主: E. coli  
  • Slide 1
90011-C07E-50
90011-C07E-5
90011-C07E-20
50 µg 
5 µg 
20 µg 
Add to Cart

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IL18/IL-18/Interleukin 18 antibody 研究背景

Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. IL-18 is an IL-1−like cytokine that requires cleavage with caspase-1 to become active, was found to increase IgE production in a CD4+ T cells-, IL-4− and STAT6−dependent fashion. IL-18 and T cell receptor−mediated stimulation could induce naïve CD4+ T cells to develop into IL-4−producing cells in vitro. Thus, caspase-1 and IL-18 may be critical in regulation of IgE production in vivo, providing a potential therapeutic target for allergic disorders. IL-18 production in primary synovial cultures and purified synovial fibroblasts was, in turn, upregulated by TNF-α and IL-1β, suggesting that monokine expression can feed back to promote Th1 cell development in synovial membrane. Besides, synergistic combinations of IL-18, IL-12, and IL-15 may be of importance in sustaining both Th1 responses and monokine production in RA.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

 IL18/IL-18/Interleukin 18 antibody 参考资料
  • Dinarello CA. (1999) IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J Allergy Clin Immunol. 103: 11-24.
  • Takeda K, et al.. (1998) Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity. 8(3): 383-90.
  • Gracie JA, et al.. (1999) A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest. 104(10): 1393-401.
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