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人 CD99L2 基因ORF全长cDNA克隆(表达载体), N-His 标签

产品数据评论实验方法
表达宿主: Human Cells  
  • Slide 1
50526-M02H-50
50526-M02H-100
50 µg 
100 µg 
Add to Cart
描述: Active  
表达宿主: Human Cells  
  • Slide 1
50526-M08H-50
50526-M08H-100
50 µg 
100 µg 
Add to Cart
反应性: Mouse  
应用 : ELISA  
    50526-RP01-400
    50526-RP01-200
    50526-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    反应性: Mouse  
    应用 : ELISA  
      50526-RP02-50
      50526-RP02-200
      50526-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart

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      CD99L2 cdna-clone 研究背景

      CD99 antigen-like protein 2, also known as MIC2-like protein 1, CD99L2 and MIC2L1, is a single-pass type I  membrane protein which belongs to the CD99 family. CD99L2 is expressed in brain, heart, lung, liver, spleen, kidney, stomach, small intestine, skeletal muscle, ovary, thymus, testis and uterus. Lower expression of CD99L2 is seen in thymus. It is also expressed in E18 uterus and placenta. CD99 and CD99L2 were required for leukocyte extravasation in the cremaster after stimulation with tumor necrosis factor-alpha, where the need for PECAM-1 is known to be bypassed. CD99 and CD99L2 act independently of PECAM-1 in leukocyte extravasation and cooperate in an independent way to help neutrophils overcome the endothelial basement membrane. CD99L2 may function as a homophilic adhesion molecule. It functions in leukocyte-endothelial cell interactions during leukocyte extravasation, and in particular, at the diapedesis step. CD99L2 does not seem to be involved in docking of leukocytes to the vessel wall or in lymphocyte diapedesis.

       CD99L2 cdna-clone 参考资料
    • Suh, YH. et al., 2003, Gene. 307: 63-76.
    • Park,S.H. Gene 2005, 353 (2):177-88.
    • Schenkel, AR et al., 2007, Cell Commun Adhes. 14 (5):227-37.
    • Bixel, MG. et al., 2010, Blood. 116 (7):1172-84. 
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