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人 FACTOR D/Adipsin 基因ORF全长cDNA克隆(表达载体), C-Flag 标签

产品数据评论实验方法
表达宿主: Human Cells  
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10160-H08H-20
10160-H08H-10
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表达宿主: Human Cells  
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50539-M08H-50
50539-M08H-20
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20 µg 
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反应性: Human  
应用 : ELISA  
    10160-MM13-50
    10160-MM13-200
    10160-MM13-100
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    反应性: Human  
    应用 : ELISA  
      10160-RP01-400
      10160-RP01-200
      10160-RP01-100
      400 µg 
      200 µg 
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      反应性: Human  
      应用 : ELISA  
        10160-R005-50
        10160-R005-100
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        反应性: Human  
        应用 : ELISA  
          10160-RP02-50
          10160-RP02-200
          10160-RP02-100
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          200 µg 
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          反应性: Mouse  
          应用 : ELISA  
            50539-RP01-400
            50539-RP01-200
            50539-RP01-100
            400 µg 
            200 µg 
            100 µg 
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            反应性: Mouse  
            应用 : ELISA  
              50539-T16-50
              50539-T16-200
              50539-T16-100
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              反应性: Mouse  
              应用 : WB  
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              50539-R104-50
              50539-R104-100
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              反应性: Mouse  
              应用 : ELISA  
                50539-R110-50
                50539-R110-100
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                100 µg 
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                反应性: Mouse  
                应用 : ELISA  
                  50539-R121-50
                  50539-R121-100
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                  100 µg 
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                  FACTOR D/Adipsin cdna-clone 研究背景

                  Complement factor D, also known as Adipsin, C3 convertase activator, Properdin factor D and CFD is a secreted protein which belongs to the peptidase S1 family. CFD / Adipsin contains one peptidase S1 domain. Complement factor D ( CFD / Adipsin ) is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. Complement factor D ( CFD / Adipsin ) has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Complement factor D ( CFD / Adipsin ) cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Complement factor D ( CFD / Adipsin ) is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency (CFD deficiency) which predisposes to invasive meningococcal disease.

                   FACTOR D/Adipsin cdna-clone 参考资料
                • Volanakis JE, et al.,1996, Protein Sci. 5 (4): 553-64.
                • Searfoss,G.H et al., 2003, J Biol Chem. 278 (46):46107-16.
                • Ukkola,O. et al., 2003, Eur J Clin Nutr. 57 (9):1073-8.
                • Ronti T, et al., 2006, Clin. Endocrinol. (Oxf) 64 (4): 355-65.
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