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小鼠 S100A8/MRP-8 基因ORF全长cDNA克隆(表达载体), C-His 标签

产品数据评论实验方法
描述: Active  
表达宿主: Baculovirus-Insect Cells  
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11138-H08B-50
11138-H08B-100
50 µg 
100 µg 
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描述: Active  
表达宿主: E. coli  
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11138-H07E-50
11138-H07E-100
50 µg 
100 µg 
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表达宿主: E. coli  
  • Slide 1
50228-M07E-50
50228-M07E-100
50 µg 
100 µg 
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反应性: Human  
应用 : ELISA  IHC-P  
  • Slide 1
  • Slide 1
11138-RP02-50
11138-RP02-200
11138-RP02-100
50 µg 
200 µg 
100 µg 
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反应性: Human  
应用 : ELISA  
    11138-RP01-400
    11138-RP01-200
    11138-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : IHC-P  
    • Slide 1
    11138-R101-50
    11138-R101-100
    50 µg 
    100 µg 
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    反应性: Mouse  
    应用 : ELISA  
      50228-RP01-400
      50228-RP01-200
      50228-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      反应性: Mouse  
      应用 : ELISA  
        50228-R008-50
        50228-R008-100
        50 µg 
        100 µg 
        Add to Cart
        反应性: Mouse  
        应用 : ELISA  IHC-P  
        • Slide 1
        50228-T24-50
        50228-T24-200
        50228-T24-100
        50 µg 
        200 µg 
        100 µg 
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        S100A8/MRP-8 cdna-clone 研究背景

        S100A8 is a member of the S100 protein family containing 2EF-hand calcium-binding motifs. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. Altered expression of S100A8 protein is associated with various diseases and cancers. S100A8 may have an immunoregulatory role by contributing to the regulation of fetal-maternal interactions. It may play a protective role and its absence may allow infiltration by maternal cells, a process eventually manifesting as resorption. The heterodimeric S100 protein complex S100A8/A9 which has been shown to be involved in inflammatory and neoplastic disorders. The complex can induce cell proliferation, or apoptosis, inflammation, collagen synthesis, and cell migration. S100A8/A9 has emerged as important pro-inflammatory mediator in acute and chronic inflammation. More recently, increased S100A8 and S100A9 levels were also detected in various human cancers, presenting abundant expression in neoplastic tumor cells as well as infiltrating immune cells. On the one hand, S100A8/A9 is a powerful apoptotic agent produced by immune cells, making it a very fascinating tool in the battle against cancer. It spears the risk to induce auto-immune response and may serve as a lead compound for cancer-selective therapeutics. In contrast, S100A8/A9 expression in cancer cells has also been associated with tumor development, cancer invasion or metastasis. Altogether, its expression and potential cytokine-like function in inflammation and in cancer suggests that S100A8/A9 may play a key role in inflammation-associated cancer.

        小鼠 S100A8/MRP-8 cdna-clone 参考资料
      • Passey RJ, et al. (1999) S100A8: emerging functions and regulation. J Leukoc Biol. 66(4): 549-56.
      • Gebhardt C, et al. (2006) S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol. 72(11): 1622-31.
      • Halayko AJ, et al. (2009) S100A8/A9: a mediator of severe asthma pathogenesis and morbidity? Can J Physiol Pharmacol. 87(10): 743-55.
      • Ghavami S, et al. (2009) S100A8/A9: a Janus-faced molecule in cancer therapy and tumorgenesis. Eur J Pharmacol. 625(1-3): 73-83.
      • Ha YS, et al. (2010) mRNA Expression of S100A8 as a Prognostic Marker for Progression of Non-Muscle-Invasive Bladder Cancer. Korean J Urol. 51(1): 15-20.
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