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人 IL-1RAcP / IL-1R3 蛋白 (His & Fc 标签)

产品数据评论实验方法
反应性: Human  
应用 : FCM  
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10121-MM05-F-25
10121-MM05-F-100
25 Test 
100 Tests 
Add to Cart
反应性: Human  
应用 : FCM  
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10121-MM05-A-25
10121-MM05-A-100
25 Test 
100 Tests 
Add to Cart
反应性: Human  
应用 : FCM  
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10121-MM05-P-25
10121-MM05-P-100
25 Test 
100 Tests 
Add to Cart
反应性: Human  
应用 : ELISA  FCM  
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10121-MM05-50
10121-MM05-200
10121-MM05-100
50 µg 
200 µg 
100 µg 
Add to Cart
反应性: Human  
应用 : ELISA  
    10121-MM04-50
    10121-MM04-200
    10121-MM04-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    反应性: Human  
    应用 : ELISA  
      10121-RP01-400
      10121-RP01-200
      10121-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      反应性: Human  
      应用 : ELISA  WB  
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      10121-T48-50
      10121-T48-200
      10121-T48-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      反应性: Human  
      应用 : ELISA  
        10121-RP02-50
        10121-RP02-200
        10121-RP02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart

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        IL-1RAcP/IL-1R3 protein 研究背景

        Interleukin-1 receptor accessory protein (IL-1RAcP) also known as Interleukin-1 receptor member 3 (IL-1R3) is a a cytokine receptor which binds interleukin 1. The IL-1 receptor accessory protein (IL1RAP) is a transmembrane protein that interacts with IL-1R and is required for IL-1 signal transduction. Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. IL-1RAcP/IL-1R3 is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. IL-1RAcP/IL-1R3 mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor.

         IL-1RAcP/IL-1R3 protein 参考资料
      • Goldbach-Mansky R, et al. (2009) Autoinflammation: the prominent role of IL-1 in monogenic autoinflammatory diseases and implications for common illnesses. J Allergy Clin Immunol. 124(6): 1141-9.
      • Johnston A, et al. (2011) IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression. J Immunol. 186(4): 2613-22.
      • Ozaki K, et al. (2001) Effect of tumor weight and tube feeding on TNF-alpha and IL-1beta mRNA expression in the brain of mice. JPEN J Parenter Enteral Nutr. 25(6): 317-22.
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