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人 IL-1RA / IL1RN 蛋白

产品数据评论实验方法
反应性: Human  
应用 : FCM  
  • Slide 1
10123-MM02-F-25
10123-MM02-F-100
25 Test 
100 Tests 
Add to Cart
反应性: Human  
应用 : FCM  
  • Slide 1
10123-R004-F-25
10123-R004-F-100
25 Test 
100 Tests 
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反应性: Human  
应用 : FCM  
  • Slide 1
10123-MM02-P-25
10123-MM02-P-100
25 Test 
100 Tests 
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反应性: Human  
应用 : IHC-P  
  • Slide 1
  • Slide 1
100099-R005-50
100099-R005-100
50 µg 
100 µg 
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反应性: Human  
应用 : FCM  IF  ICC/IF  
  • Slide 1
  • Slide 1
10123-MM02-50
10123-MM02-200
10123-MM02-100
50 µg 
200 µg 
100 µg 
Add to Cart
反应性: Human  
应用 : FCM  IF  ICC/IF  
  • Slide 1
  • Slide 1
10123-R004-50
10123-R004-100
50 µg 
100 µg 
Add to Cart
反应性: Human  
应用 : ELISA  
    10123-R001-50
    10123-R001-100
    50 µg 
    100 µg 
    Add to Cart
    反应性: Human  
    应用 : ELISA  
      10123-RP01-400
      10123-RP01-200
      10123-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      反应性: Human  
      应用 : ELISA  
        10123-MM12-50
        10123-MM12-200
        10123-MM12-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        反应性: Human  
        应用 : ELISA  IHC-P  
        • Slide 1
        • Slide 1
        10123-RP02-50
        10123-RP02-200
        10123-RP02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart

        HP100096 

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        IL-1RA/IL1RN protein 研究背景

        Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. A polymorphism of this protein encoding gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. IL-1RA/IL1RN may inhibit the activity of IL-1 by binding to its receptor and it has no IL-1 like activity. Genetic variation in IL-1RA/IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in IL-1RA/IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA) which is also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis, and pustulosis from birth.

         IL-1RA/IL1RN protein 参考资料
      • Langdahl BL, et al. (2000) Osteoporotic fractures are associated with an 86-base pair repeat polymorphism in the interleukin-1--receptor antagonist gene but not with polymorphisms in the interleukin-1beta gene. J Bone Miner. 15 (3): 402-14.
      • El-Omar EM, et al. (2000) Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature. 404 (6776): 398-402.
      • Steinkasserer A, et al. (1992) The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci. Genomics. 13 (3): 654-7.
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