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人 IL1R1 / CD121a HEK293 过表达细胞裂解液 (阳性对照)

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表达宿主: Human Cells  
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10126-H02H-50
10126-H02H-100
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100 µg 
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表达宿主: Human Cells  
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10126-H08H-50
10126-H08H-20
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表达宿主: Human Cells  
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10126-HCCH-50
10126-HCCH-100
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表达宿主: Human Cells  
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50807-M08H-50
50807-M08H-100
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表达宿主: Human Cells  
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50807-M02H-50
50807-M02H-100
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100 µg 
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表达宿主: Human Cells  
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80028-R08H-50
80028-R08H-100
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描述: Active  
表达宿主: Human Cells  
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80028-R06H-50
80028-R06H-100
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表达宿主: Human Cells  
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90279-C02H-50
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表达宿主: Human Cells  
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90279-C08H-50
90279-C08H-100
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反应性: Human  
应用 : ELISA  
    10126-MM10-50
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    反应性: Human  
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      10126-MM08-50
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      10126-MM08-1
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      1 mg 
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      反应性: Human  
      应用 : ELISA  WB  IP  
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      10126-RP02-50
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      反应性: Human  
      应用 : ELISA  
        10126-RP01-400
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        400 µg 
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        反应性: Human  
        应用 : ELISA  
          10126-R024-50
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          反应性: Mouse  
          应用 : FCM  
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          50807-R191-A-25
          50807-R191-A-100
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          反应性: Mouse  
          应用 : FCM  
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          50807-R191-P-25
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          反应性: Mouse  
          应用 : ELISA  
            50807-R075-50
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            反应性: Mouse  
            应用 : ELISA  
              50807-R002-50
              50807-R002-100
              50807-R002-1
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              反应性: Mouse  
              应用 : FCM  
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              50807-R191-50
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              反应性: Mouse  
              应用 : ELISA  
                50807-T16-50
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                反应性: Mouse  
                应用 : ELISA  
                  50807-RP01-400
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                  反应性: Rat  
                  应用 : FCM  
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                  80028-R007-F-25
                  80028-R007-F-100
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                  反应性: Rat  
                  应用 : FCM  
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                  80028-R007-P-25
                  80028-R007-P-100
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                  反应性: Rat  
                  应用 : ELISA  
                    80028-RP01-400
                    80028-RP01-200
                    80028-RP01-100
                    400 µg 
                    200 µg 
                    100 µg 
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                    反应性: Rat  
                    应用 : ELISA  WB  
                    • Slide 1
                    80028-RP02-50
                    80028-RP02-200
                    80028-RP02-100
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                    200 µg 
                    100 µg 
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                    反应性: Rat  
                    应用 : ELISA  
                      80028-R027-50
                      80028-R027-100
                      50 µg 
                      100 µg 
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                      反应性: Rat  
                      应用 : ELISA  
                        80028-MM08-50
                        80028-MM08-200
                        80028-MM08-100
                        80028-MM08-1
                        50 µg 
                        200 µg 
                        100 µg 
                        1 mg 
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                        反应性: Rat  
                        应用 : ELISA  
                        • Slide 1
                        80028-R007-50
                        80028-R007-100
                        50 µg 
                        100 µg 
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                        反应性: Rat  
                        应用 : 
                          80028-MM10-50
                          80028-MM10-200
                          80028-MM10-100
                          80028-MM10-1
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                          200 µg 
                          100 µg 
                          1 mg 
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                          反应性: Cynomolgus  
                          应用 : ELISA  
                            90279-MM02-50
                            90279-MM02-200
                            90279-MM02-100
                            50 µg 
                            200 µg 
                            100 µg 
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                            反应性: Cynomolgus  
                            应用 : ELISA  
                              90279-T16-50
                              90279-T16-200
                              90279-T16-100
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                              200 µg 
                              100 µg 
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                              IL1R1/IL-1R1/IL-1 RI lysate_category 研究背景

                              Interleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokine induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R AcP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.

                               IL1R1/IL-1R1/IL-1 RI lysate_category 参考资料
                            • Dale M, et al. (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q.". Genomics 57 (1): 177-9.
                            • Joos L, et al. (2001). "Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers.". Thorax 56 (11): 863-6.
                            • Vigers GP, et al. (1997). "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta.". Nature 386 (6621): 190-4.
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