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人 CD171 / N-CAML1 / L1CAM 蛋白 (His 标签)

产品数据评论实验方法
反应性: Human  
应用 : FCM  
  • Slide 1
10140-R014-F-25
10140-R014-F-100
25 Test 
100 Tests 
Add to Cart
反应性: Human  
应用 : FCM  
  • Slide 1
10140-MM03-A-25
10140-MM03-A-100
25 Test 
100 Tests 
Add to Cart
反应性: Human  
应用 : FCM  
  • Slide 1
10140-R014-P-25
10140-R014-P-100
25 Test 
100 Tests 
Add to Cart
反应性: Human  
应用 : FCM  
  • Slide 1
  • Slide 1
10140-MM03-P-25
10140-MM03-P-100
25 Test 
100 Tests 
Add to Cart
反应性: Human  
应用 : ELISA  
    10140-RP01-400
    10140-RP01-200
    10140-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    反应性: Human  
    应用 : 
      10140-R001-50
      10140-R001-100
      10140-R001-1
      50 µg 
      100 µg 
      1 mg 
      Add to Cart
      反应性: Human  
      应用 : ELISA  
        10140-MM01-50
        10140-MM01-200
        10140-MM01-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        反应性: Human  
        应用 : ELISA  
          10140-R004-50
          10140-R004-100
          50 µg 
          100 µg 
          Add to Cart
          反应性: Human  
          应用 : IHC-P  FCM  IF  ICC/IF  
          • Slide 1
          • Slide 1
          • Slide 1
          10140-R014-50
          10140-R014-100
          10140-R014-1
          50 µg 
          100 µg 
          1 mg 
          Add to Cart
          反应性: Human  
          应用 : ELISA  
            10140-RP02-50
            10140-RP02-200
            10140-RP02-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart
            反应性: Human  
            应用 : FCM  
            • Slide 1
            10140-MM03-50
            10140-MM03-200
            10140-MM03-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart
            反应性: Mouse  
            应用 : 
            • Slide 1
            101901-T08-50
            101901-T08-200
            101901-T08-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart

            CD171/L1CAM 蛋白Related Products

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            CD171/L1CAM protein 研究背景

            L1 cell adhesion molecule (L1CAM), also designated as CD171, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and in a variety of cancer cells, including some common types of human cancer. L1CAM interacts with a variety of ligands including axonin-1, CD9, neurocan and intergrins, and it has been revealed that the RGD motif in the sixth Ig domain of L1CAM is a binding site for integrins, thus important for nuclear signaling. Disruption of L1CAM function causes three X-linked neurological syndromes, i.e. hydrocephalus, MASA syndrome (mental retardation, aphasia, shuffling gait and adducted thumbs) and spastic paraplegia syndrome. Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate and promoted cell transformation and tumorigenicity. Recent work has identified L1CAM (CD171) as a novel marker for human carcinoma progression, and a candidate for anti-cancer therapy.

             CD171/L1CAM protein 参考资料
          • Meier F, et al. (2006) The adhesion molecule L1 (CD171) promotes melanoma progression. Int J Cancer. 119(3): 549-55.
          • Gavert N, et al. (2008) L1-CAM in cancerous tissues. Expert Opin Biol Ther. 8(11): 1749-57.
          • Issa Y, et al. (2009) Enhanced L1CAM expression on pancreatic tumor endothelium mediates selective tumor cell transmigration. J Mol Med. 87(1): 99-112.
          • Weidle UH, et al. (2009) L1-CAM as a target for treatment of cancer with monoclonal antibodies. Anticancer Res. 29(12): 4919-31.
          • Raveh S, et al. (2009) L1 cell adhesion molecule (L1CAM) in invasive tumors. Cancer Lett. 282(2): 137-45.
          • Wolterink S, et al. (2010) Therapeutic antibodies to human L1CAM: functional characterization and application in a mouse model for ovarian carcinoma. Cancer Res. 70(6): 2504-15.
          • 请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”