Text Size:AAA

人 UBASH3A 基因ORF全长cDNA克隆(表达载体), N-HA 标签

产品数据评论实验方法
表达宿主: E. coli  
  • Slide 1
13847-H07E-20
13847-H07E-100
20 µg 
100 µg 
Add to Cart
反应性: Human  
应用 : ELISA  
    13847-R101-50
    13847-R101-100
    50 µg 
    100 µg 
    Add to Cart
    反应性: Human  
    应用 : ELISA  IHC-P  
    • Slide 1
    13847-T24-50
    13847-T24-200
    13847-T24-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    反应性: Human  
    应用 : ELISA  
      13847-RP01-400
      13847-RP01-200
      13847-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart

      UBASH3A cDNARelated Products

      Related Products

      Featured Reagent Products

      UBASH3A cdna-clone 研究背景

      UBASH3A is a member of the T-cell ubiquitin ligand (TULA) family. This family consists of two members. Both of them can negatively regulate T-cell signaling. UBASH3A can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of UBASH3A gene results in multiple transcript variants. It interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. UBASH3A promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. UBASH3A also exhibits negligigle protein tyrosine phosphatase activity at neutral pH. It may act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. It may also inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.

       UBASH3A cdna-clone 参考资料
    • Collingwood TS, et al. (2007) T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis.". J. Biol. Chem. 282 (42): 30920-8.
    • Smirnova EV, et al. (2008) TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion. Virology. 372(1):10-23.
    • Wattenhofer M, et al. (2001) Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains. Hum Genet. 108(2):140-7.
    • 请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”