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小鼠 Leukotriene A4 Hydrolase/LTA4H 基因ORF全长cDNA克隆(表达载体), C-His 标签

产品数据评论实验方法
表达宿主: Baculovirus-Insect Cells  
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10276-H08B-20
10276-H08B-10
20 µg 
10 µg 
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描述: Active  
表达宿主: Baculovirus-Insect Cells  
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50268-M08B-50
50268-M08B-20
50 µg 
20 µg 
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反应性: Human  
应用 : ELISA  
    10276-R455-50
    10276-R455-100
    50 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  WB  IF  IP  ICC/IF  
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    • Slide 1
    • Slide 1
    10276-R201-50
    10276-R201-100
    50 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  WB  IP  
    • Slide 1
    • Slide 1
    10276-RP02-50
    10276-RP02-200
    10276-RP02-100
    50 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  
      10276-R457-50
      10276-R457-100
      50 µg 
      100 µg 
      Add to Cart
      反应性: Mouse  
      应用 : ELISA  
        50268-RP01-400
        50268-RP01-200
        50268-RP01-100
        400 µg 
        200 µg 
        100 µg 
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        反应性: Mouse  
        应用 : ELISA  WB  IP  
        • Slide 1
        • Slide 1
        50268-RP02-50
        50268-RP02-200
        50268-RP02-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart

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        Leukotriene A4 Hydrolase/LTA4H cdna-clone 研究背景

        Leukotriene A-4 hydrolase, also known as LTA-4 hydrolase, Leukotriene A (4) hydrolase, LTA4H and LTA4, is cytoplasm protein which belongs to the peptidase M1 family. LTA4H hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4). This enzyme also has some peptidase activity. The leukotrienes (LTs) are a class of structurally related lipid mediators involved in the development and maintenance of inflammatory and allergic reactions. In the biosynthesis of LTs, arachidonic acid was converted into the unstable intermediate epoxide LTA4, which may in turn be conjugated with glutathione to form the spasmogenic LTC4, or hydrolyzed into the proinflammatory lipid mediator LTB4 in a reaction catalyzed by Leukotriene A4 hydrolase (LTA4H). LTB4 is a classical chemoattractant of human neutrophils and triggers adherence and aggregation of leukocytes to vascular endothelium, and also modulates immune responses. As a bifunctional zinc metalloenzyme, LTA4H also exhibits an anion-dependant arginyl aminopeptidase activity of high efficiency and specificity in addition to its epoxide hydrolase activity. LTA4H is regarded as a therapeutic target for inflammation.

        小鼠 Leukotriene A4 Hydrolase/LTA4H cdna-clone 参考资料
      • Mancini, JA. et al.,1995, Eur. J. Biochem. 231: 65-71.
      • Orning, L. et al., 1994, J. Biol. Chem. 269: 11269-73.
      • Rudberg, PC. et al., 2004, J. Biol. Chem. 279: 27376-82.
      • Qiu, H. et al., 2006, Proc. Natl. Acad. Sci. USA. 103: 8161-6.
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