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人 SCN2B 基因ORF全长cDNA克隆(表达载体), N-HA 标签

产品数据评论实验方法
表达宿主: Human Cells  
  • Slide 1
13859-H02H-20
13859-H02H-100
20 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
13859-H08H-20
13859-H08H-100
20 µg 
100 µg 
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反应性: Human  
应用 : ELISA  
    13859-RP01-400
    13859-RP01-200
    13859-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : 
    • Slide 1
    13859-T24-50
    13859-T24-200
    13859-T24-100
    50 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  
      13859-T16-50
      13859-T16-200
      13859-T16-100
      50 µg 
      200 µg 
      100 µg 
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      SCN2B cdna-clone 研究背景

      SCN2B plays a key role in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. Voltage-gated sodium channels (NaV) are composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits. Alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments.They are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. SCN2B causes an increase in the plasma membrane surface area and in its folding into microvilli. SCN2B also interacts with TNR and may play a crucial role in clustering and regulation of activity of sodium channels at nodes of ranvier.

       SCN2B cdna-clone 参考资料
    • Kimura K, et al. (2006) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome Res. 16(1):55-65.
    • Tan BH, et al. (2010) Sudden infant death syndrome-associated mutations in the sodium channel beta subunits. Heart Rhythm. 7(6):771-8.
    • Watanabe H, et al. (2009) Mutations in sodium channel beta1- and beta2-subunits associated with atrial fibrillation. Circ Arrhythm Electrophysiol. 2(3):268-75. Kimura K et al., 2006, Genome Res. 16(1):55-65.
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