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小鼠 AGRP 基因全长ORF克隆 (表达载体), C端His标签

产品数据评论实验方法
表达宿主: Human Cells  
  • Slide 1
10070-H02H-5
10070-H02H-10
10070-H02H-20
5 µg 
10 µg 
20 µg 
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表达宿主: Human Cells  
  • Slide 1
10070-H08H-10
10070-H08H-20
10 µg 
20 µg 
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表达宿主: Human Cells  
  • Slide 1
10070-H01H-20
10070-H01H-100
20 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
50276-M01H-100
50276-M01H-200
100 µg 
200 µg 
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表达宿主: Human Cells  
  • Slide 1
50276-M08H-100
50276-M08H-200
100 µg 
200 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
50276-M02H-100
50276-M02H-200
100 µg 
200 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
  • Slide 1
90196-C04H-200
90196-C04H-100
200 µg 
100 µg 
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AGRP cdna-clone 研究背景

Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally.

Mouse AGRP cdna-clone 参考资料
  • Ilnytska O, et al. (2008) The role of the Agouti-Related Protein in energy balance regulation. Cell Mol Life Sci. 65(17): 2721-31.
  • Pritchard LE, et al. (2005) Agouti-related protein: more than a melanocortin-4 receptor antagonist? Peptides. 26(10): 1759-70.
  • Sttz AM, et al. (2005) The agouti-related protein and its role in energy homeostasis. Peptides. 26(10): 1771-81.
  • Millhauser GL, et al. (2003) Loops and links: structural insights into the remarkable function of the agouti-related protein. Ann N Y Acad Sci. 994: 27-35.
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