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小鼠 LRPAP1/A2MRAP 基因ORF全长cDNA克隆(表达载体), C-His 标签

产品数据评论实验方法
描述: Active  
表达宿主: Human Cells  
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11100-H08H-50
11100-H08H-100
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100 µg 
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描述: Active  
表达宿主: Human Cells  
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50281-M08H-50
50281-M08H-100
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100 µg 
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反应性: Human  
应用 : ELISA  WB  IHC-P  IP  
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11100-MM01-50
11100-MM01-200
11100-MM01-100
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200 µg 
100 µg 
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反应性: Human  
应用 : IHC-P  
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11100-M003-50
11100-M003-200
11100-M003-100
50 µg 
200 µg 
100 µg 
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反应性: Human  
应用 : ELISA  WB  IHC-P  IP  
  • Slide 1
  • Slide 1
  • Slide 1
  • Slide 1
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11100-RP02-50
11100-RP02-200
11100-RP02-100
50 µg 
200 µg 
100 µg 
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反应性: Human  
应用 : WB  
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11100-MM34-50
11100-MM34-200
11100-MM34-100
50 µg 
200 µg 
100 µg 
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反应性: Human  
应用 : ELISA  
    11100-RP01-400
    11100-RP01-200
    11100-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  IP  
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    11100-M105-50
    11100-M105-200
    11100-M105-100
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    200 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  WB  IF  IP  ICC/IF  
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    11100-R004-50
    11100-R004-100
    50 µg 
    100 µg 
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    反应性: Mouse  
    应用 : ELISA  WB  IHC-P  IP  
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    50281-R009-50
    50281-R009-100
    50 µg 
    100 µg 
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    反应性: Mouse  
    应用 : ELISA  WB  IHC-P  IP  
    • Slide 1
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    50281-RP02-50
    50281-RP02-200
    50281-RP02-100
    50 µg 
    200 µg 
    100 µg 
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    反应性: Mouse  
    应用 : IHC-P  
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    50281-R011-50
    50281-R011-100
    50 µg 
    100 µg 
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    反应性: Mouse  
    应用 : ELISA  
      50281-RP01-400
      50281-RP01-200
      50281-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart

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      LRPAP1/A2MRAP cdna-clone 研究背景

      Receptor-associated protein (RAP) is a molecular chaperone for low density lipoprotein receptor-related protein (LRP), which plays a key role in cholesterol metabolism. The lipoprotein receptor-related protein (LRP) is an endocytic receptor for several ligands, such as alpha2-macroglobulin (alpha2 M) and apolipoprotein E. LRP is involved in the clearance of lipids from the bloodstream and is expressed in the atherosclerotic plaque. The LRP-associated protein (LRPAP in humans, RAP in mice) acts as a chaperone protein, stabilizing the nascent LRP peptide in the endoplasmic reticulum and Golgi complex. Alpha-2-macroglobulin receptor-associated protein, also known as low density lipoprotein receptor-related protein-associated protein 1, RAP and LRPAP1, is a 39 kDa protein and a member of the alpha-2-MRAP family. It is a receptor antagonist that interacts with several members of the low density lipoprotein (LDL) receptor gene family. Upon binding to these receptors, LRPAP1 inhibits all ligand interactions with the receptors. LRPAP1 is present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. It binds with LRP1B and the binding is followed by internalization and degradation. LRPAP1 interacts with LRP1/alpha-2-macroglobulin receptor and LRP2 (previously called glycoprotein 330), and may be involved in the pathogenesis of membrane glomerular nephritis. LRPAP1 together with LRP2 forms the Heymann nephritis antigenic complex. LRP2 is expressed in epithelial cells of the thyroid, where it can serve as a receptor for the protein thyroglobulin. Intron 5 insertion/deletion polymorphism of RAP gene (LRPAP1) has been implicated in other diseases sharing etiology with gallstone disease (GSD). The LRPAP1 insertion/deletion polymorphism influences cholesterol homeostasis and may confer risk for gallstone disease and gallbladder carcinoma (GBC) incidence usually parallels with the prevalence of cholelithiosis. The genetic variations at the LRPAP1 locus may modulate Alzheimer disease (AD) phenotype beyond risk for disease. In addition, the variation at the LRPAP1 gene could contribute to the risk of developing an early episode of myocardial infarction (MI).

      小鼠 LRPAP1/A2MRAP cdna-clone 参考资料
    • Gonzlez P, et al. (2002) Variation in the lipoprotein receptor-related protein, alpha2-macroglobulin and lipoprotein receptor-associated protein genes in relation to plasma lipid levels and risk of early myocardial infarction. Coron Artery Dis. 13(5): 251-4.
    • Schutte DL, et al. (2003) A LRPAP1 intronic insertion/deletion polymorphism and phenotypic variability in Alzheimer disease. Res Theory Nurs Pract. 17(4): 301-19?
    • Pandey SN, et al. (2006) Lipoprotein receptor associated protein (LRPAP1) insertion/deletion polymorphism: association with gallbladder cancer susceptibility. Int J Gastrointest Cancer. 37(4): 124-8.
    • Dixit M, et al. (2006) Association of low density lipoprotein receptor related protein-associated protein (LRPAP1) gene insertion/deletion polymorphism with gallstone disease.J Gastroenterol Hepatol. 21(5): 847-9.
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