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人 IGF1R / CD221 杆状病毒-昆虫 过表达细胞裂解液 (阳性对照)

产品数据评论实验方法
表达宿主: Baculovirus-Insect Cells  
  • Slide 1
10164-H20B1-50
10164-H20B1-20
50 µg 
20 µg 
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描述: Active  
表达宿主: Human Cells  
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10164-H08H-50
10164-H08H-100
50 µg 
100 µg 
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反应性: Human  
应用 : FCM  
  • Slide 1
  • Slide 1
10164-R012-F-25
10164-R012-F-100
25 Test 
100 Tests 
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反应性: Human  
应用 : FCM  
  • Slide 1
  • Slide 1
10164-R012-P-25
10164-R012-P-100
25 Test 
100 Tests 
Add to Cart
反应性: Human  
应用 : FCM  
  • Slide 1
10164-R012-A-25
10164-R012-A-100
25 Test 
100 Tests 
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反应性: Human  
应用 : 
    10164-MM07-50
    10164-MM07-200
    10164-MM07-100
    10164-MM07-1
    50 µg 
    200 µg 
    100 µg 
    1 mg 
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    反应性: Human  
    应用 : ELISA  
      10164-MM04-50
      10164-MM04-200
      10164-MM04-100
      50 µg 
      200 µg 
      100 µg 
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      反应性: Human  
      应用 : FCM  IF  ICC/IF  
      • Slide 1
      • Slide 1
      10164-R012-50
      10164-R012-100
      50 µg 
      100 µg 
      Add to Cart
      反应性: Human  
      应用 : ELISA  
        10164-R011-50
        10164-R011-100
        50 µg 
        100 µg 
        Add to Cart
        反应性: Human  
        应用 : ELISA  
          10164-RP02-50
          10164-RP02-200
          10164-RP02-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          反应性: Human  
          应用 : ELISA  
            10164-RP01-400
            10164-RP01-200
            10164-RP01-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart

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            IGF1R/CD221/IGF-I R lysate_category 研究背景

            The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide-linked heterotetrameric transmembrane protein consisting of two α and two β subunits, and among which, the α subunit is extracellular while the β subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. IGF1R signalling pathway is activated in the mammalian nervous system from early developmental stages. Its major effect on developing neural cells is to promote their growth and survival. This pathway can integrate its action with signalling pathways of growth and morphogenetic factors that induce cell fate specification and selective expansion of specified neural cell subsets. Modulation of cell migration is another possible role that IGF1R activation may play in neurogenesis. In the mature brain, IGF-I binding sites have been found in different regions of the brain, and multiple reports confirmed a strong neuroprotective action of the IGF-IR against different pro-apoptotic insults. IGF1R is an important signaling molecule in cancer cells and plays an essential role in the establishment and maintenance of the transformed phenotype. Inhibition of IGF1R signaling thus appears to be a promising strategy to interfere with the growth and survival of cancer cells. IGF1R is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.

            Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

             IGF1R/CD221/IGF-I R lysate_category 参考资料
          • Bhr C, et al. (2004) The insulin like growth factor-1 receptor (IGF-1R) as a drug target: novel approaches to cancer therapy. Growth Horm IGF Res. 14 (4): 287-95.
          • Riedemann J, et al. (2006) IGF1R signalling and its inhibition. Endocr Relat Cancer. 13 Suppl 1: 33-43.
          • Gualco E, et al. (2009) IGF-IR in neuroprotection and brain tumors. Front Biosci. 14: 352-75.
          • Annenkov A. (2009) The insulin-like growth factor (IGF) receptor type 1 (IGF1R) as an essential component of the signalling network regulating neurogenesis. Mol Neurobiol. 40 (3): 195-215.
          • 请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”