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人 IL2Ra / CD25 HEK293 过表达细胞裂解液 (阳性对照)

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描述: Active  
表达宿主: Human Cells  
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10165-H02H-50
10165-H02H-100
50 µg 
100 µg 
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描述: Active  
表达宿主: Human Cells  
  • Slide 1
10165-H08H-50
10165-H08H-20
50 µg 
20 µg 
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表达宿主: Human Cells  
  • Slide 1
50292-M08H-50
50292-M08H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
90265-C08H-50
90265-C08H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
90265-C02H-50
90265-C02H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
90265-CCCH-5
90265-CCCH-20
90265-CCCH-100
5 µg 
20 µg 
100 µg 
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反应性: Human  
应用 : FCM  
  • Slide 1
10165-R216-A-25
10165-R216-A-100
25 Test 
100 Tests 
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反应性: Human  
应用 : 
  • Slide 1
  • Slide 1
10165-R216-F-25
10165-R216-F-100
25 Test 
100 Tests 
Add to Cart
反应性: Human  
应用 : FCM  
  • Slide 1
  • Slide 1
10165-R216-P-25
10165-R216-P-100
25 Test 
100 Tests 
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反应性: Human  
应用 : 
  • Slide 1
10165-R216-C-25
10165-R216-C-100
25 Test 
100 Tests 
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反应性: Human  
应用 : 
  • Slide 1
10165-MM17-P-25
10165-MM17-P-100
25 Test 
100 Tests 
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反应性: Human  
应用 : 
  • Slide 1
10165-MM17-F-25
10165-MM17-F-100
25 Test 
100 Tests 
Add to Cart
反应性: Human  
应用 : ELISA  
    10165-R702-50
    10165-R702-100
    50 µg 
    100 µg 
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    反应性: Human  
    应用 : 
    • Slide 1
    10165-MM17-50
    10165-MM17-200
    10165-MM17-100
    50 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : FCM  
    • Slide 1
    10165-R216-50
    10165-R216-100
    50 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  
      10165-MM14-50
      10165-MM14-200
      10165-MM14-100
      50 µg 
      200 µg 
      100 µg 
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      反应性: Human  
      应用 : ELISA  
        10165-RP01-400
        10165-RP01-200
        10165-RP01-100
        400 µg 
        200 µg 
        100 µg 
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        反应性: Human  
        应用 : ELISA  
          10165-RP02-50
          10165-RP02-200
          10165-RP02-100
          50 µg 
          200 µg 
          100 µg 
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          反应性: Mouse  
          应用 : FCM  
          • Slide 1
          • Slide 1
          50292-R051-F-25
          50292-R051-F-100
          25 Test 
          100 Tests 
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          反应性: Mouse  
          应用 : FCM  
          • Slide 1
          • Slide 1
          50292-R051-P-25
          50292-R051-P-100
          25 Test 
          100 Tests 
          Add to Cart
          反应性: Mouse  
          应用 : FCM  
          • Slide 1
          • Slide 1
          50292-R051-A-25
          50292-R051-A-100
          25 Test 
          100 Tests 
          Add to Cart
          反应性: Mouse  
          应用 : FCM  
          • Slide 1
          • Slide 1
          50292-R049-F-25
          50292-R049-F-100
          25 Test 
          100 Tests 
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          反应性: Mouse  
          应用 : FCM  
          • Slide 1
          • Slide 1
          50292-R049-P-25
          50292-R049-P-100
          25 Test 
          100 Tests 
          Add to Cart
          反应性: Mouse  
          应用 : FCM  
          • Slide 1
          50292-R049-C-25
          50292-R049-C-100
          25 Test 
          100 Tests 
          Add to Cart
          反应性: Mouse  
          应用 : FCM  
          • Slide 1
          • Slide 1
          50292-R049-A-25
          50292-R049-A-100
          25 Test 
          100 Tests 
          Add to Cart
          反应性: Mouse  
          应用 : FCM  
          • Slide 1
          50292-R051-C-25
          50292-R051-C-100
          25 Test 
          100 Tests 
          Add to Cart
          反应性: Mouse  
          应用 : FCM  
          • Slide 1
          50292-R049-50
          50292-R049-100
          50 µg 
          100 µg 
          Add to Cart
          反应性: Mouse  
          应用 : ELISA  
            50292-RP01-400
            50292-RP01-200
            50292-RP01-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart
            反应性: Mouse  
            应用 : ELISA  
              50292-RP02-50
              50292-RP02-200
              50292-RP02-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart
              反应性: Mouse  
              应用 : FCM  
              • Slide 1
              50292-R051-50
              50292-R051-100
              50 µg 
              100 µg 
              Add to Cart
              反应性: Mouse  
              应用 : ELISA  
                50292-R186-50
                50292-R186-100
                50 µg 
                100 µg 
                Add to Cart

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                IL2RA/IL-2RA/CD25 lysate_category 研究背景

                CD25 (alpha-chain of IL-2 receptor, or IL2RA), is a type I transmembrane glycoprotein with a signal peptide, an extracellular region, a transmembrane region, and a cytoplasmic domain. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling. The IL2RA (CD25) gene is a substantial component of the high-affinity receptor molecule highly expressed by activated T lymphocytes. Recently, a strong evidence was obtained for the involvement of IL-2RA in conferring susceptibility to type 1 diabetes (T1D). Cancer growth and development is associated with the stimulation of the innate immune system, including enhanced interleukin 2 receptor (IL-2R) expression in immune cells and its shedding into the circulation in a soluble form of sIL-2Ralpha. In most haematological malignancies, including different types of leukaemias and lymphomas, sIL-2Ralpha has been found to be released directly from the surface of neoplastic cells thus reflecting the tumour bulk, turnover and activity. Several studies have proved that not only lymphoid cancer cells, but also some non-lymphoid cancer cells, express IL-2R on their surface. They include malignant melanoma and carcinomas of the kidney, head and neck, oesophagus and lung. Thus, sIL-2Ralpha is elevated in most proliferative disturbances of the hematopoietic system and in many solid tumors.

                Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                 IL2RA/IL-2RA/CD25 lysate_category 参考资料
              • Driesen J, et al. (2008) CD25 as an immune regulatory molecule expressed on myeloid dendritic cells. Immunobiology. 213(9-10): 849-58.
              • Olejniczak K, et al. (2008) Biological properties of interleukin 2 and its role in pathogenesis of selected diseases--a review. Med Sci Monit. 14(10): RA179-89.
              • Chistiakov DA, et al. (2008) The crucial role of IL-2/IL-2RA-mediated immune regulation in the pathogenesis of type 1 diabetes, an evidence coming from genetic and animal model studies. Immunol Lett. 118(1): 1-5.
              • Bien E, et al. (2008) Serum soluble interleukin 2 receptor alpha in human cancer of adults and children: a review. Biomarkers. 13(1): 1-26.
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