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小鼠 Raf-1/RAF1 基因ORF全长cDNA克隆(表达载体), C-His 标签

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反应性: Human  
应用 : WB  
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101053-T32-50
101053-T32-200
101053-T32-100
50 µg 
200 µg 
100 µg 
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Raf-1/RAF1 cdna-clone 研究背景

RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

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