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人 DKK1 / Dkk-1 蛋白 (His 标签)

产品数据评论实验方法
反应性: Human  
应用 : ELISA  WB  
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10170-RP01-400
10170-RP01-200
10170-RP01-100
400 µg 
200 µg 
100 µg 
Add to Cart
反应性: Human  
应用 : ELISA  IHC-P  
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  • Slide 1
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10170-T16-50
10170-T16-200
10170-T16-100
50 µg 
200 µg 
100 µg 
Add to Cart
反应性: Human  
应用 : ELISA  
    10170-MM03-50
    10170-MM03-200
    10170-MM03-100
    10170-MM03-1
    50 µg 
    200 µg 
    100 µg 
    1 mg 
    Add to Cart
    反应性: Human  
    应用 : 
      10170-MM08-50
      10170-MM08-200
      10170-MM08-100
      10170-MM08-1
      50 µg 
      200 µg 
      100 µg 
      1 mg 
      Add to Cart
      反应性: Human  
      应用 : ELISA  WB  IP  
      • Slide 1
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      10170-RP02-50
      10170-RP02-200
      10170-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      反应性: Human  
      应用 : ELISA  WB  
      • Slide 1
      10170-R004-50
      10170-R004-100
      50 µg 
      100 µg 
      Add to Cart
      反应性: Human  
      应用 : B/N  
        10170-R015-500
        10170-R015-200
        500 µg 
        200 µg 
        Add to Cart
        反应性: Rhesus  
        应用 : ELISA  
          11089-T16-50
          11089-T16-200
          11089-T16-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          反应性: Rhesus  
          应用 : ELISA  WB  
          • Slide 1
          11089-T48-50
          11089-T48-200
          11089-T48-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          反应性: Rhesus  
          应用 : ELISA  
            11089-RP01-400
            11089-RP01-200
            11089-RP01-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart

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            DKK1/Dkk-1 protein 研究背景

            Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers.

             DKK1/Dkk-1 protein 参考资料
          • Horwitz EM. (2004) Dkk-1-mediated expansion of adult stem cells. Trends Biotechnol. 22(8): 386-8.
          • Jiang T, et al. (2009) Clinical significance of serum DKK-1 in patients with gynecological cancer. Int J Gynecol Cancer. 19(7): 1177-81.
          • 请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”