Text Size:AAA

小鼠 IL-28B/IFN-lambda-3 基因ORF全长cDNA克隆(表达载体), N-Myc 标签

产品数据评论实验方法
表达宿主: Yeast  
  • Slide 1
11890-H08Y-20
11890-H08Y-100
20 µg 
100 µg 
Add to Cart
描述: Active  
表达宿主: Human Cells  
  • Slide 1
11890-H08H-50
11890-H08H-5
11890-H08H-20
50 µg 
5 µg 
20 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
51306-M08H-50
51306-M08H-20
50 µg 
20 µg 
Add to Cart
反应性: Human  
应用 : ELISA  
    11890-R120-50
    11890-R120-100
    50 µg 
    100 µg 
    Add to Cart
    反应性: Human  
    应用 : ELISA  
      11890-RP02-50
      11890-RP02-100
      50 µg 
      100 µg 
      Add to Cart
      反应性: Human  
      应用 : ELISA  
        11890-RP01-400
        11890-RP01-200
        11890-RP01-100
        400 µg 
        200 µg 
        100 µg 
        Add to Cart
        反应性: Mouse  
        应用 : ELISA  
          51306-R001-50
          51306-R001-100
          50 µg 
          100 µg 
          Add to Cart
          反应性: Mouse  
          应用 : ELISA  
            51306-T16-50
            51306-T16-200
            51306-T16-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart

            IL-28B/IFN-lambda-3 cDNARelated Products

            Related Products

            Featured Reagent Products

            IL-28B/IFN-lambda-3 cdna-clone 研究背景

            Interleukin-28B (IL-28B) also known as Interferon lambda-3 and IFN-lambda-3, belongs to the type III interferon family of cytokines and are highly similar to IL-29. IL-28B belongs to the newly described interferon lambda (IFNλ) family of cytokines. IL-28B is a cytokine with immunomodulatory activity. It functions in Up-regulating MHC class I antigen expression. IL-28B displays potent antiviral activity and antitumor activity. This cytokine serves as ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. IL-28B, like IL-12, is capable of robustly enhancing adaptive immunity. Moreover, we describe for the first time how IL-28B reduces regulatory T-cell populations during DNA vaccination, whereas IL-12 increases this cellular subset. We also show that IL-28B, unlike IL-12, is able to increase the percentage of splenic CD8+ T cells in vaccinated animals, and that these cells are more granular and have higher antigen-specific cytolytic degranulation compared with cells taken from animals that received IL-12 as an adjuvant.

            小鼠 IL-28B/IFN-lambda-3 cdna-clone 参考资料
          • Ge D, et al.. (2009) Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature. 461(7262): 399-401.
          • Morrow MP, et al.. (2009) Comparative ability of IL-12 and IL-28B to regulate Treg populations and enhance adaptive cellular immunity. Blood. 113(23): 5868-77.
          • Sheppard P, et al.. (2003) IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat Immunol. 4(1): 63-8.
          • 请注意:所有产品都是“仅用于科研,而不能用于诊断或治疗用途”