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人 Prolactin Receptor 基因ORF全长cDNA克隆(表达载体), C-Flag 标签

产品数据评论实验方法
表达宿主: Human Cells  
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10278-H08H-50
10278-H08H-100
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100 µg 
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表达宿主: Human Cells  
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50457-M03H-50
50457-M03H-100
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100 µg 
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表达宿主: Human Cells  
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50457-M08H-50
50457-M08H-100
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100 µg 
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表达宿主: Human Cells  
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80062-R08H-50
80062-R08H-100
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100 µg 
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反应性: Human  
应用 : FCM  
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10278-R204-P-25
10278-R204-P-100
25 Test 
100 Tests 
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反应性: Human  
应用 : FCM  
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10278-R204-A-25
10278-R204-A-100
25 Test 
100 Tests 
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反应性: Human  
应用 : ELISA  
    10278-MM13-50
    10278-MM13-200
    10278-MM13-100
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    200 µg 
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    反应性: Human  
    应用 : ELISA  FCM  IF  ICC/IF  
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    • Slide 1
    10278-R204-50
    10278-R204-100
    10278-R204-1
    50 µg 
    100 µg 
    1 mg 
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    反应性: Human  
    应用 : ELISA  
      10278-RP01-50
      10278-RP01-200
      10278-RP01-100
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      200 µg 
      100 µg 
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      反应性: Human  
      应用 : ELISA  
        10278-RP02-400
        10278-RP02-200
        10278-RP02-100
        400 µg 
        200 µg 
        100 µg 
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        反应性: Human  
        应用 : 
          10278-R313-50
          10278-R313-100
          10278-R313-1
          50 µg 
          100 µg 
          1 mg 
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          反应性: Rat  
          应用 : ELISA  
            80062-RP01-400
            80062-RP01-200
            80062-RP01-100
            400 µg 
            200 µg 
            100 µg 
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            反应性: Rat  
            应用 : ELISA  
              80062-R001-50
              80062-R001-100
              50 µg 
              100 µg 
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              反应性: Rat  
              应用 : ELISA  
                80062-R113-50
                80062-R113-100
                50 µg 
                100 µg 
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                反应性: Rat  
                应用 : ELISA  
                  80062-T16-50
                  80062-T16-200
                  80062-T16-100
                  50 µg 
                  200 µg 
                  100 µg 
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                  Prolactin Receptor cdna-clone 研究背景

                  Prolactin receptor (PRLR) is a single-pass transmembrane receptor belonging to the type â…  cytokine receptor superfamily, and contains two fibronectin type-â…¢ domains. All class 1 ligands activate their respective receptors by clustering mechanisms. Ligand binding results in the transmembrane PRLR dimerization, followed by phosphorylation and activation of the molecules invloved in the signaling pathways, such as Jak-STAT, Ras/Raf/MAPK. The PRLR contains no intrinsic tyrosine kinase cytoplasmic domain but associates with a cytoplasmic tyrosine kinase, JAK2. PRLR mainly serves as the receptor for the pituitary hormone prolactin (PRL), a secreted hormone that affects reproduction and homeostasis in vertebrates. PRLR can be regulated by an interplay of two different mechanisms, PRL or ovarian steroid hormones independently or in combination in a tissue-specific manner. The role of the hormone prolactin (PRL) in the pathogenesis of breast cancer is mediated by its cognate receptor (PRLR). Ubiquitin-dependent degradation of the PRLR that negatively regulates PRL signaling is triggered by PRL-mediated phosphorylation of PRLR on Ser349 followed by the recruitment of the beta-transducin repeats-containing protein (beta-TrCP) ubiquitin-protein isopeptide ligase. which altered PRLR stability may directly influence the pathogenesis of breast cancer.

                   Prolactin Receptor cdna-clone 参考资料
                • Bole-Feysot C, et al. (1998) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev. 19(3): 225-68.
                • Goffin V, et al. (1999) From the molecular biology of prolactin and its receptor to the lessons learned from knockout mice models. Genet Anal. 15(3-5): 189-201.
                • Li Y, et al. (2006) Stabilization of prolactin receptor in breast cancer cells. Oncogene. 25(13): 1896-902.
                • Shao R, et al. (2008) Differences in prolactin receptor (PRLR) in mouse and human fallopian tubes: evidence for multiple regulatory mechanisms controlling PRLR isoform expression in mice. Biol Reprod. 79(4): 748-57.
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