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TrkA / NTRK1 抗体, 兔多抗

产品数据评论实验方法
描述: Active  
表达宿主: Human Cells  
  • Slide 1
11073-H03H-50
11073-H03H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
11073-H08H-50
11073-H08H-100
50 µg 
100 µg 
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表达宿主: E. coli  
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11073-H07E1-50
11073-H07E1-100
50 µg 
100 µg 
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描述: Active  
表达宿主: Human Cells  
  • Slide 1
11073-H07H2-50
11073-H07H2-100
50 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
51103-M02H-50
51103-M02H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
51103-M08H-50
51103-M08H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
80404-R08H-50
80404-R08H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
80404-R02H-50
80404-R02H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
70101-D01H-50
70101-D01H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
70101-D07H-50
70101-D07H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
65159-T08H-50
65159-T08H-200
50 µg 
200 µg 
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TrkA/NTRK1 ELISA配对抗体

检测限: 312.5 pg/ml
SEK11073-5
SEK11073-15
5 Plates 
15 Plates 
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TrkA/NTRK1 抗体Related Products

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TrkA/NTRK1 antibody 研究背景

TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors. The presence of NTRK1 leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TRKA gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. It was originally identified as an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas. TRKA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. NTRK1 has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. It also activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. Defects in NTRK1 are a cause of congenital insensitivity to pain with anhidrosis and thyroid papillary carcinoma.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

 TrkA/NTRK1 antibody 参考资料
  • Lambiase A, et al. (2005) Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3. Natl Acad Sci. 102 (46):16795-800.
  • Benito-Gutiérrez E, et al. (2006) Origin and evolution of the Trk family of neurotrophic receptors. Mol Cell Neurosci. 31(2):179-92.
  • Martin-Zanca D, et al. (1986) A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature. 319(6056):743-8.
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