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CRIP2 抗体, 兔多抗

产品数据评论实验方法
表达宿主: Baculovirus-Insect Cells  
  • Slide 1
14552-H20B-20
14552-H20B-100
20 µg 
100 µg 
Add to Cart
表达宿主: Baculovirus-Insect Cells  
  • Slide 1
14552-HNCB-50
14552-HNCB-20
50 µg 
20 µg 
Add to Cart

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CRIP2 antibody 研究背景

CRIP2 is a putative transcription factor. It has a widespread tissue expression and is highly expressed in heart. CRIP2 contains two LIM zinc-binding domains. CRIP2 may participate in the differentiation of smooth muscle tissue. It also plays an important role in esophageal squamous cell carcinoma (ESCC) tumorigenesis. CRIP2 acts as a transcription repressor of the NF-κB-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis. It interacts with the NF-κB/p65 to inhibit its DNA-binding ability to the promoter regions of the major proangiogenesis cytokines critical for tumor progression, including IL6, IL8, and VEGF. In conclusion, we provide compelling evidence that CRIP2 acts as a transcription repressor of the NF-κB-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis.

 CRIP2 antibody 参考资料
  • Chang DF. et al., 2003, Dev Cell. 4 (1):107-18.
  • Huber A. et al., 2000, J Biol Chem. 275 (8): 5504-11.
  • Karim MA. et al., 1996, Genomics. 31 (2): 167-76.
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