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大鼠 EIF5A 基因ORF全长cDNA克隆(表达载体)

产品数据评论实验方法
表达宿主: E. coli  
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15096-H07E-20
15096-H07E-100
20 µg 
100 µg 
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反应性: Human  
应用 : WB  IF  ICC/IF  
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15096-T34-50
15096-T34-200
15096-T34-100
50 µg 
200 µg 
100 µg 
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EIF5A cdna-clone 研究背景

EIF-5A, also known as EIF5, functions in start site selection as a GTPase accelerating protein (GAP) for the eukaryotic translation initiation factor (eIF) 2•GTP•tRNA ternary complex within the ribosome-bound pre-initiation complex. In protein synthesis initiation, eIF2 functions in its GTP-bound state to deliver initiator methionyl-tRNA to the small ribosomal subunit and is necessary for protein synthesis in all cells. EIF-5A stabilizes the binding of GDP to eIF2 and is therefore a bi-functional protein that acts as a GDP dissociation inhibitor (GDI). EIF-5A also interacts with eIF1 and eIF3 and binds the eIF2-GTP/Met-tRNA ternary complex along with the 40S ribosome subunit.

大鼠 EIF5A cdna-clone 参考资料
  • Jenkins ZA. et al., 2001, Genomics. 71 (1): 101-9.
  • Guan XY. et al., 2001, Cancer Res. 61 (9): 3806-9.
  • Strausberg RL. et al., 2003, Proc Natl Acad Sci. 99 (26): 16899-903.
  • Clement PM. et al., 2003, Eur J Biochem. 270 (21): 4254-63.
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