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人 Progranulin/Granulin 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

产品数据评论实验方法
表达宿主: Human Cells  
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10826-H08H-50
10826-H08H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
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50396-M08H-50
50396-M08H-100
50 µg 
100 µg 
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反应性: Human  
应用 : ELISA  
    10826-R007-50
    10826-R007-100
    50 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  IHC-P  
    • Slide 1
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    10826-RP04-50
    10826-RP04-200
    10826-RP04-100
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    200 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  IF  ICC/IF  
    • Slide 1
    10826-MM02-50
    10826-MM02-200
    10826-MM02-100
    10826-MM02-1
    50 µg 
    200 µg 
    100 µg 
    1 mg 
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    反应性: Human  
    应用 : 
      10826-MM10-50
      10826-MM10-200
      10826-MM10-100
      10826-MM10-1
      50 µg 
      200 µg 
      100 µg 
      1 mg 
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      反应性: Human  
      应用 : ELISA  
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      10826-RP03-400
      10826-RP03-200
      10826-RP03-100
      400 µg 
      200 µg 
      100 µg 
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      反应性: Mouse  
      应用 : ELISA  IHC-P  
      • Slide 1
      • Slide 1
      50396-RP02-50
      50396-RP02-200
      50396-RP02-100
      50 µg 
      200 µg 
      100 µg 
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      反应性: Mouse  
      应用 : ELISA  
        50396-R034-50
        50396-R034-100
        50396-R034-1
        50 µg 
        100 µg 
        1 mg 
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        反应性: Mouse  
        应用 : ELISA  
          50396-RP01-400
          50396-RP01-200
          50396-RP01-100
          400 µg 
          200 µg 
          100 µg 
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          反应性: Mouse  
          应用 : 
            50396-R019-50
            50396-R019-100
            50396-R019-1
            50 µg 
            100 µg 
            1 mg 
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            反应性: Mouse  
            应用 : ELISA  
              50396-R017-50
              50396-R017-100
              50 µg 
              100 µg 
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              Progranulin/Granulin cdna-clone 研究背景

              &Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Granulin expression inhibited Tat transactivation, and tethering experiments showed that this effect was due, at least in part, to a direct action on cyclin T1 in the absence of Tat.

               Progranulin/Granulin cdna-clone 参考资料
            • Hoque M, et al. (2003) The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription. Mol Cell Biol. 23(5): 1688-702.
            • Bateman A, et al. (1990) Granulins, a novel class of peptide from leukocytes. Biochem Biophys Res Commun. 173(3): 1161-8.
            • Trinh DP, et al. (1999) Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins. Biochem Biophys Res Commun. 256(2): 299-306.
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