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人 HPRG/HRG 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

产品数据评论实验方法
描述: Active  
表达宿主: Human Cells  
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10836-H08H-50
10836-H08H-20
10836-H08H-100
50 µg 
20 µg 
100 µg 
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表达宿主: Human Cells  
  • Slide 1
81643-R08H-20
81643-R08H-100
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100 µg 
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反应性: Human  
应用 : ELISA  
    10836-RP03-400
    10836-RP03-200
    10836-RP03-100
    400 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  
      10836-R028-50
      10836-R028-100
      50 µg 
      100 µg 
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      反应性: Human  
      应用 : ELISA  
        10836-RP04-50
        10836-RP04-200
        10836-RP04-100
        50 µg 
        200 µg 
        100 µg 
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        反应性: Human  
        应用 : ELISA  
          10836-MM01-50
          10836-MM01-200
          10836-MM01-100
          10836-MM01-1
          50 µg 
          200 µg 
          100 µg 
          1 mg 
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          反应性: Human  
          应用 : ELISA  
            10836-MM02-50
            10836-MM02-200
            10836-MM02-100
            50 µg 
            200 µg 
            100 µg 
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            HPRG/HRG cdna-clone 研究背景

            Histidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets, and contains an unusually large amount of histidine and proline. In human, five distinct domains are recognized in the mature HPRG molecule. There are two N-terminal cystatin-like modules (aa 19 - 254) and one His-Pro-rich region (aa 350 - 497) that is flanked by two Pro-rich segments (aa 276 - 321 and 498 - 525). The His-Pro-rich region contains 10 tandem repeats with an HHPHG motif, and the N- and C-termini are linked by a disulfide bond. The specific functions of HRG remain unclear, but it is known that the protein binds heme, dyes and divalent metal ions. It inhibits rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. HPRG is evolutionarily, functionally and structurally related to cleaved high molecular weight kininogen (HKa), an anti-angiogenic polypeptide that stimulates apoptosis of proliferating endothelial cells through binding to cell-surface tropomyosin. The antiangiogenic activity of the multidomain plasma protein HPRG is localized to its histidine-proline-rich (H/P) domain and has recently been shown to be mediated, at least partially, through binding to cell-surface tropomyosin in fibroblast growth factor-2-activated endothelial cells.

             HPRG/HRG cdna-clone 参考资料
          • Guan X, et al. (2004) Histidine-proline rich glycoprotein (HPRG) binds and transduces anti-angiogenic signals through cell surface tropomyosin on endothelial cells. Thromb Haemost. 92(2): 403-12.
          • Doate F, et al. (2004) Peptides derived from the histidine-proline domain of the histidine-proline-rich glycoprotein bind to tropomyosin and have antiangiogenic and antitumor activities. Cancer Res. 64(16): 5812-7.
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