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人 CD150 / SLAM / SLAMF1 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

产品数据评论实验方法
描述: Active  
表达宿主: Human Cells  
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10837-H08H-50
10837-H08H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
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80349-R02H-50
80349-R02H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
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80349-R08H-50
80349-R08H-100
50 µg 
100 µg 
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反应性: Human  
应用 : ELISA  
    10837-MM05-50
    10837-MM05-200
    10837-MM05-100
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    200 µg 
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    反应性: Human  
    应用 : 
      10837-MM02-50
      10837-MM02-200
      10837-MM02-100
      10837-MM02-1
      50 µg 
      200 µg 
      100 µg 
      1 mg 
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      反应性: Human  
      应用 : 
        10837-R110-50
        10837-R110-100
        10837-R110-1
        50 µg 
        100 µg 
        1 mg 
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        反应性: Human  
        应用 : ELISA  IHC-P  
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        10837-R008-50
        10837-R008-100
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        100 µg 
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        反应性: Human  
        应用 : ELISA  IHC-P  
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        10837-RP01-50
        10837-RP01-200
        10837-RP01-100
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        200 µg 
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        反应性: Human  
        应用 : ELISA  WB  
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        10837-RP02-400
        10837-RP02-200
        10837-RP02-100
        400 µg 
        200 µg 
        100 µg 
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        反应性: Rat  
        应用 : ELISA  
          80349-T16-50
          80349-T16-200
          80349-T16-100
          50 µg 
          200 µg 
          100 µg 
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          反应性: Rat  
          应用 : ELISA  
            80349-RP01-400
            80349-RP01-200
            80349-RP01-100
            400 µg 
            200 µg 
            100 µg 
            Add to Cart

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            CD150 / SLAM / SLAMF1 cdna-clone 研究背景

            CD150/signaling lymphocytic activation molecule (SLAM) is a cell surface sialylated phosphoglycoprotein and belongs to the CD2 subset of the Ig superfamily of type I transmembrane glycoproteins. The CD150 receptor is expressed on thymocytes, activated and memory T cells, B cells, platelets, natural killer T cells, and mature dendritic cells, and is also detected on tumor cells of Hodgkin's lymphoma (HL) and diffuse large B-cell lymphoma with an activated B cell phenotype. Additionally, it is the immune cell receptor for measles virus (MV). As a self-ligand, CD150 performs diverse immunologic functions including T/B-cell costimulation, induction of IFN-&gamma in Th1 T-cell clones, redirection of Th2 clones to a Th1 or Th0 phenotype, and inhibition of apoptosis in B cells. Furthermore, CD150 was shown to be the second receptor for measles virus in addition to CD46, and the distribution of SLAM on various cell lines is consistent with their susceptibility to clinical isolates of measles virus.

             CD150 / SLAM / SLAMF1 cdna-clone 参考资料
          • Tatsuo H, et al. (2002) The morbillivirus receptor SLAM (CD150). Microbiol Immunol. 46(3): 135-42.
          • Sidorenko SP, et al. (2003)The dual-function CD150 receptor subfamily: the viral attraction. Nat Immunol. 4(1): 19-24.
          • Yurchenko MY, et al. (2010) CD150 regulates JNK1/2 activation in normal and Hodgkin's lymphoma B cells. Immunol Cell Biol. 88(5): 565-74.
          • Leonard VH, et al. (2010) Measles virus selectively blind to signaling lymphocytic activation molecule (SLAM ; CD150) is attenuated and induces strong adaptive immune responses in rhesus monkeys. J Virol. 84(7): 3413-20.
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