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人 14-3-3 beta/YWHAB 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

产品数据评论实验方法
表达宿主: E. coli  
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10843-H09E-50
10843-H09E-100
50 µg 
100 µg 
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表达宿主: E. coli  
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10843-HNCE-50
10843-HNCE-100
50 µg 
100 µg 
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表达宿主: E. coli  
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90022-CNCE-20
90022-CNCE-100
20 µg 
100 µg 
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反应性: Human  
应用 : FCM  
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10843-MM03-A-25
10843-MM03-A-100
25 Test 
100 Tests 
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反应性: Human  
应用 : FCM  
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10843-MM03-C-25
10843-MM03-C-100
25 Test 
100 Tests 
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反应性: Human  
应用 : FCM  
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10843-MM03-P-25
10843-MM03-P-100
25 Test 
100 Tests 
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反应性: Human  
应用 : FCM  
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10843-MM03-F-25
10843-MM03-F-100
25 Test 
100 Tests 
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反应性: Human  
应用 : ELISA  WB  IP  
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10843-RP02-50
10843-RP02-200
10843-RP02-100
50 µg 
200 µg 
100 µg 
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反应性: Human  
应用 : ELISA  
    10843-RP01-400
    10843-RP01-200
    10843-RP01-100
    400 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  FCM  IF  ICC/IF  
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    10843-MM03-50
    10843-MM03-200
    10843-MM03-100
    50 µg 
    200 µg 
    100 µg 
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    反应性: Cynomolgus  
    应用 : ELISA  WB  IP  
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    90022-MM05-50
    90022-MM05-200
    90022-MM05-100
    50 µg 
    200 µg 
    100 µg 
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    反应性: Cynomolgus  
    应用 : 
    • Slide 1
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    90022-T36-50
    90022-T36-200
    90022-T36-100
    50 µg 
    200 µg 
    100 µg 
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    14-3-3 beta/YWHAB cdna-clone 研究背景

    14-3-3 beta / YWHAB is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 beta / YWHAB is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. 14-3-3 beta / YWHAB interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. 14-3-3 beta / YWHAB has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 beta / YWHAB binding negatively regulates RSK1 activity to maintain signal specificity and that association/dissociation of the 14-3-3beta-RSK1 complex is likely to be important for mitogen-mediated RSK1 activation.

     14-3-3 beta/YWHAB cdna-clone 参考资料
  • Tommerup N, et al. (1996) Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization. Genomics. 33(1): 149-50.
  • Jin YH, et al. (2008) Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53. Biochem Biophys Res Commun. 368(3): 690-5.
  • Sekimoto T, et al. (2004) 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). EMBO J. 23(9): 1934-42.
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