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人 Neurexophilin-1/NXPH1 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

产品数据评论实验方法
表达宿主: Human Cells  
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50865-M08H-50
50865-M08H-100
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100 µg 
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表达宿主: Human Cells  
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80047-R08H-50
80047-R08H-100
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100 µg 
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反应性: Mouse  
应用 : ELISA  
    50865-T16-50
    50865-T16-200
    50865-T16-100
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    200 µg 
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    反应性: Rat  
    应用 : ELISA  
      80047-R021-50
      80047-R021-100
      50 µg 
      100 µg 
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      反应性: Rat  
      应用 : IHC-P  
      • Slide 1
      • Slide 1
      80047-R001-50
      80047-R001-100
      50 µg 
      100 µg 
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      反应性: Rat  
      应用 : ELISA  
        80047-T16-50
        80047-T16-200
        80047-T16-100
        50 µg 
        200 µg 
        100 µg 
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        反应性: Rat  
        应用 : ELISA  
          80047-RP01-400
          80047-RP01-200
          80047-RP01-100
          400 µg 
          200 µg 
          100 µg 
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          Neurexophilin-1/NXPH1 cdna-clone 研究背景

          Neurexophilin-1, or NXPH1 is a secreted glycoprotein, which belongs to the Neurexophilin family. The Neurexophilin family contain at least four genes and resembles a neuropeptide, suggesting a function as an endogenous ligand for alpha-neurexins. The mammalian brains contain four genes for neurexophilins the products of which share a common structure composed of five domains: an N-terminal signal peptide, a variable N-terminal domain, a highly conserved central domain that is N-glycosylated, a short linker region, and a conserved C-terminal domain that is cysteine-rich. Neurexophilin-1 constitutes a secreted cysteine-rich glycoprotein, forms a very tight complex with alpha neurexins, a group of proteins that promote adhesion between dendrites and axons. Neurexophilins 1 and 3 but not 4 (neurexophilin 2 is not expressed in rodents) bind to a single individual LNS domain, the second overall LNS domain in all three alpha-neurexins.

           Neurexophilin-1/NXPH1 cdna-clone 参考资料
        • Missler M, et al. (1998) Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit. J Biol Chem. 273(52): 34716-23.
        • Missler M, et al. (1998) Neurexophilins form a conserved family of neuropeptide-like glycoproteins. J Neurosci. 18(10): 3630-8.
        • Petrenko AG, et al. (1996) Structure and evolution of neurexophilin. J Neurosci. 16(14): 4360-9.
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