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大鼠 Carbonic Anhydrase III 基因ORF全长cDNA克隆(表达载体)

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描述: Active  
表达宿主: E. coli  
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10503-H08E-50
10503-H08E-100
50 µg 
100 µg 
Add to Cart
反应性: Human  
应用 : ELISA  
    10503-MM09-50
    10503-MM09-200
    10503-MM09-100
    50 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  
      10503-RP01-400
      10503-RP01-200
      10503-RP01-100
      400 µg 
      200 µg 
      100 µg 
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      反应性: Human  
      应用 : ELISA  IHC-P  
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      10503-RP02-50
      10503-RP02-200
      10503-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      反应性: Human  
      应用 : WB  IP  
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      • Slide 1
      10503-R006-50
      10503-R006-100
      50 µg 
      100 µg 
      Add to Cart
      反应性: Human  
      应用 : IHC-P  
      • Slide 1
      10503-R002-50
      10503-R002-100
      50 µg 
      100 µg 
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      Carbonic Anhydrase III cdna-clone 研究背景

      Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Carbonic anhydrases (CAs) form a family of enzymes that catalyze the rapid conversion of carbon dioxide and water to bicarbonate and protons, a reaction that occurs rather slowly in the absence of a catalyst. The active site of most carbonic anhydrases contains a zinc ion, they are therefore classified as metalloenzymes. Several forms of carbonic anhydrase occur in nature. The primary function of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues. Plants contain a different form called β-carbonic anhydrase, which, from an evolutionary standpoint, is a distinct enzyme, but participates in the same reaction and also uses a zinc ion in its active site.

      Carbonic anhydrase 3, also known as Carbonate dehydratase III, CA-III and CA3, is a cytoplasm protein which belongs to the alpha-carbonic anhydrase family. CA3 is activated by proton donors such as imidazole and the dipeptide histidylhistidine. It is inhibited by coumarins and sulfonamide derivatives such as acetazolamide. At 6 weeks gestation, transcripts accumulate at low levels in the somites and at high levels throughout the notochord. As gestation continues, CA3 becomes abundant in all developing muscle masses and continues at high to moderate levels in the notochord.

      大鼠 Carbonic Anhydrase III cdna-clone 参考资料
    • Ivanov, S.V. et al., 1998, Proc. Natl. Acad. Sci. USA 95:12596-601.
    • Sowden J. et al., 1998, Gene 214:157- 65.
    • Strausberg, R.L. et al., 2002, Proc. Natl. Acad. Sci. USA 99:16899-903.
    • Liao, S.Y. et al., 2003, J. Med. Genet. 40: 257-62.
    • Bataller,L. et al., 2004, Ann Neurol  56 (4): 575-9.
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