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人 IL32 transcript variant 1 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

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表达宿主: Human Cells  
  • Slide 1
11064-H08H-50
11064-H08H-100
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100 µg 
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反应性: Human  
应用 : ELISA  
    11064-R030-50
    11064-R030-100
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    100 µg 
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    反应性: Human  
    应用 : WB  
    • Slide 1
    11064-MM12-50
    11064-MM12-200
    11064-MM12-100
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    200 µg 
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    反应性: Human  
    应用 : ELISA  
      11064-R403-50
      11064-R403-100
      11064-R403-1
      50 µg 
      100 µg 
      1 mg 
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      反应性: Human  
      应用 : ELISA  
        11064-T16-50
        11064-T16-200
        11064-T16-100
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        200 µg 
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        反应性: Human  
        应用 : WB  IP  
        • Slide 1
        • Slide 1
        100285-T36-50
        100285-T36-200
        100285-T36-100
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        200 µg 
        100 µg 
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        反应性: Human  
        应用 : ELISA  
          11064-RP01-400
          11064-RP01-200
          11064-RP01-100
          400 µg 
          200 µg 
          100 µg 
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          反应性: Human  
          应用 : 
            11064-R034-50
            11064-R034-100
            11064-R034-1
            50 µg 
            100 µg 
            1 mg 
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            反应性: Human  
            应用 : ELISA  WB  
            • Slide 1
            11064-T48-50
            11064-T48-200
            11064-T48-100
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            200 µg 
            100 µg 
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            IL32 cdna-clone 研究背景

            IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines, and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma and delta) are the most representative IL-32 transcripts, and gamma isoform of IL-32 is the most active, although all isoforms are biologically active. IL-32, a cytokine produced mainly by T, natural killer, and epithelial cells induces significant amounts of TNFalpha and MIP-2 and increases the production of both cytokines in a dose-dependent manner. IL-32 has been implicated in inflammatory disorders, mycobacterium tuberculosis infections, inflammatory bowel disease, and influenza A virus infection, as well as in some autoimmune diseases, such as rheumatoid arthritis, ulcerative colitis and in human stomach cancer, human lung cancer and breast cancer tissues. Thus, IL-32 expression might be valuable as a biomarker for cancer.

             IL32 cdna-clone 参考资料
          • Felaco P, et al. (2009) IL-32: a newly-discovered proinflammatory cytokine. J Biol Regul Homeost Agents. 23(3): 141-7.
          • Kobayashi H, et al. (2009) Molecular characterization of IL-32 in human endothelial cells. Cytokine. 46(3): 351-8.
          • Meyer N, et al. (2010) IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis. J Allergy Clin Immunol. 125(4): 858-865.
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