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人 NAP-2 / PPBP / CXCL7 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

产品数据评论实验方法
表达宿主: E. coli  
  • Slide 1
10878-H07E-50
10878-H07E-20
50 µg 
20 µg 
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表达宿主: E. coli  
  • Slide 1
50145-M07E-20
50145-M07E-10
20 µg 
10 µg 
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表达宿主: E. coli  
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50145-M07E1-20
50145-M07E1-10
20 µg 
10 µg 
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表达宿主: Yeast  
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80066-R08Y-20
80066-R08Y-100
20 µg 
100 µg 
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表达宿主: Human Cells  
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80066-R01H-20
80066-R01H-10
20 µg 
10 µg 
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表达宿主: Yeast  
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90132-C08Y-20
90132-C08Y-100
20 µg 
100 µg 
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表达宿主: Human Cells  
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90132-C04H-20
90132-C04H-10
20 µg 
10 µg 
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反应性: Human  
应用 : ELISA  
    10878-T16-50
    10878-T16-200
    10878-T16-100
    50 µg 
    200 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  
      10878-RP01-400
      10878-RP01-200
      10878-RP01-100
      400 µg 
      200 µg 
      100 µg 
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      反应性: Mouse  
      应用 : ELISA  WB  IP  
      • Slide 1
      • Slide 1
      50145-T52-50
      50145-T52-200
      50145-T52-100
      50 µg 
      200 µg 
      100 µg 
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      NAP-2 / PPBP / CXCL7 cDNARelated Products

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      NAP-2 / PPBP / CXCL7 cdna-clone 研究背景

      Pro-platelet basic protein (PPBP) is also known as Chemokine (C-X-C motif) ligand 7 (CXCL7) and nucleosome assembly protein (Nap-2). Nap-2 / PPBP / CXCL7 is released in large amounts from platelets following their activation and is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. Nap-2 / PPBP / CXCL7 has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. Nap-2 is a ligand for CXCR1 and CXCR2, and Nap-2, Nap-2 (73), Nap-2 (74), Nap-2 (1-66), and most potent Nap-2 (1-63) are chemoattractants and activators for neutrophils.

      Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

       NAP-2 / PPBP / CXCL7 cdna-clone 参考资料
    • Walz A, et al. (1989) Effects of the neutrophil-activating peptide NAP-2, platelet basic protein, connective tissue-activating peptide III and platelet factor 4 on human neutrophils. J Exp Med. 170(5):1745-50.
    • Walz A, et al. (1990) Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases. J Exp Med. 171(2): 449-54.
    • Loetscher P, et al. (1994) Both interleukin-8 receptors independently mediate chemotaxis. Jurkat cells transfected with IL-8R1 or IL-8R2 migrate in response to IL-8, GRO alpha and NAP-2. FEBS Lett. 341(2-3): 187-92.
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