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人 PTPN6 ORF mammalian expression plasmid, N-Flag 标签

产品数据评论实验方法
表达宿主: Baculovirus-Insect Cells  
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50894-M20B-20
50894-M20B-100
20 µg 
100 µg 
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反应性: Mouse  
应用 : ELISA  WB  IP  
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50894-T52-50
50894-T52-200
50894-T52-100
50 µg 
200 µg 
100 µg 
Add to Cart

PTPN6/SHP1 cDNARelated Products

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PTPN6/SHP1 cdna-clone 研究背景

PTPN6 is an enzyme which belongs to the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of PTPN6 contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of PTPN6 with its substrates. PTPN6 is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. It has been shown that PTPN6 interacts with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling.

 PTPN6/SHP1 cdna-clone 参考资料
  • Yu CL, et al. (2000) Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation. J Biol Chem. 275(1):599-604.
  • Wu DW, et al. (2000) SH2-Containing protein tyrosine phosphatase-1 (SHP-1) association with Jak2 in UT-7/Epo cells. Blood Cells Mol Dis. 26(1):15-24.
  • Jiao H, et al. (1996) Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Mol Cell Biol. 16(12):6985-92.
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