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人 BAMBI/NMA 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

产品数据评论实验方法
表达宿主: Human Cells  
  • Slide 1
10890-H08H-50
10890-H08H-20
50 µg 
20 µg 
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表达宿主: Human Cells  
  • Slide 1
50895-M08H-50
50895-M08H-20
50 µg 
20 µg 
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表达宿主: Human Cells  
  • Slide 1
50895-M02H-50
50895-M02H-20
50 µg 
20 µg 
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反应性: Human  
应用 : 
    10890-MM02-50
    10890-MM02-200
    10890-MM02-100
    10890-MM02-1
    50 µg 
    200 µg 
    100 µg 
    1 mg 
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    反应性: Human  
    应用 : ELISA  
      10890-R211-50
      10890-R211-100
      50 µg 
      100 µg 
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      反应性: Human  
      应用 : ELISA  
        10890-MM04-50
        10890-MM04-200
        10890-MM04-100
        50 µg 
        200 µg 
        100 µg 
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        反应性: Human  
        应用 : ELISA  WB  
        • Slide 1
        10890-RP02-50
        10890-RP02-200
        10890-RP02-100
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        200 µg 
        100 µg 
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        反应性: Human  
        应用 : 
          10890-MM10-50
          10890-MM10-200
          10890-MM10-100
          10890-MM10-1
          50 µg 
          200 µg 
          100 µg 
          1 mg 
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          反应性: Human  
          应用 : ELISA  
            10890-RP01-400
            10890-RP01-200
            10890-RP01-100
            400 µg 
            200 µg 
            100 µg 
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            反应性: Human  
            应用 : ELISA  
              10890-MM06-50
              10890-MM06-200
              10890-MM06-100
              50 µg 
              200 µg 
              100 µg 
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              反应性: Human  
              应用 : ELISA  
                10890-T16-50
                10890-T16-200
                10890-T16-100
                50 µg 
                200 µg 
                100 µg 
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                反应性: Mouse  
                应用 : ELISA  
                  50895-T16-50
                  50895-T16-200
                  50895-T16-100
                  50 µg 
                  200 µg 
                  100 µg 
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                  BAMBI/NMA cdna-clone 研究背景

                  BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/ threonine kinase domain but with an extracellular domain and a short cytoplasmic region that share sequence similarities with type 1 receptors, whose members have functions in signal transduction in various developing and pathological processes. BAMBI competes with the type 1 receptor, a receptor of the transforming growth factor-beta (TGF-beta), through functioning as negative regulators of TGF-beta by limiting the signaling range of the TGF-beta family during early embryogenesis. The expression of BAMBI can be induced by accumulated beta-catenin and BMP. The expression level of BAMBI was found aberrantly elevated in most colorectal and hepatocellular carcinomas relative to the corresponding non-cancerous tissues. It suggestes that beta-catenin and TGF-beta interfere growth arrest by inducing the expression of BAMBI, and this may contribute to colorectal and hepatocellular tumorigenesis.

                   BAMBI/NMA cdna-clone 参考资料
                • Sekiya T, et al. (2003) Identification of BMP and Activin Membrane-bound Inhibitor (BAMBI), an Inhibitor of Transforming Growth Factor- Signaling, as a Target of the -Catenin Pathway in Colorectal Tumor Cells. The Journal of Biological Chemistry. 279:6840-6.
                • Shi YG, et al. (2003) Mechanisms of TGF- Signaling from Cell Membrane to the Nucleus. Cell. 113(6): 685-700.
                • Wanninger J, et al. (2011) Adiponectin induces the transforming growth factor decoy receptor BAMBI in human hepatocytes. FEBS Lett. 585(9):1338-44.
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