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人 IL17RA/IL-17RA/CD217 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

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表达宿主: Human Cells  
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10895-H03H-200
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描述: Active  
表达宿主: Human Cells  
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10895-H08H-50
10895-H08H-100
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描述: Active  
表达宿主: Human Cells  
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50328-M08H-50
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表达宿主: Human Cells  
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50328-M02H-200
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表达宿主: Human Cells  
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80190-R08H-200
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表达宿主: Human Cells  
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80190-R02H-200
80190-R02H-100
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表达宿主: Human Cells  
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90127-C02H-200
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反应性: Human  
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10895-R004-F-25
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反应性: Human  
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10895-MM06-A-25
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反应性: Human  
应用 : 
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10895-MM06-F-25
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10895-MM06-P-25
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反应性: Human  
应用 : ELISA  
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    反应性: Human  
    应用 : WB  
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    10895-MM07-50
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    反应性: Human  
    应用 : ELISA  
      10895-R012-50
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      反应性: Human  
      应用 : B/N  
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      10895-R004-500
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      反应性: Human  
      应用 : ELISA  
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        反应性: Human  
        应用 : ELISA  
          10895-RP01-400
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          反应性: Rat  
          应用 : ELISA  
            80190-MM05-50
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            反应性: Rat  
            应用 : ELISA  
              80190-RP01-400
              80190-RP01-200
              80190-RP01-100
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              反应性: Rat  
              应用 : ELISA  
                80190-T16-50
                80190-T16-200
                80190-T16-100
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                200 µg 
                100 µg 
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                IL17RA/IL-17RA/CD217 cdna-clone 研究背景

                Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.

                 IL17RA/IL-17RA/CD217 cdna-clone 参考资料
              • Gaffen SL. (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9 (8): 556-67.
              • Johansen C, et al.. (2009) Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol. 160 (2): 319-24.
              • Yao Z, et al.. (1997) Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9 (11): 794-800.
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