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人 Cyclin E1/CCNE1 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

产品数据评论实验方法
表达宿主: Baculovirus-Insect Cells  
  • Slide 1
10902-H07B-50
10902-H07B-20
50 µg 
20 µg 
Add to Cart
表达宿主: Baculovirus-Insect Cells  
  • Slide 1
10902-H20B-20
10902-H20B-100
20 µg 
100 µg 
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表达宿主: Baculovirus-Insect Cells  
  • Slide 1
10902-HNCB-20
10902-HNCB-100
20 µg 
100 µg 
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表达宿主: Baculovirus-Insect Cells  
  • Slide 1
50896-M20B-20
50896-M20B-100
20 µg 
100 µg 
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反应性: Human  
应用 : ELISA  WB  IHC-P  
  • Slide 1
  • Slide 1
10902-RP02-50
10902-RP02-200
10902-RP02-100
50 µg 
200 µg 
100 µg 
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反应性: Human  
应用 : ELISA  
    10902-RP01-400
    10902-RP01-200
    10902-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart
    反应性: Human  
    应用 : IHC-P  
    • Slide 1
    • Slide 1
    • Slide 1
    10902-MM11-50
    10902-MM11-200
    10902-MM11-100
    50 µg 
    200 µg 
    100 µg 
    Add to Cart
    反应性: Human  
    应用 : IF  ICC/IF  
    • Slide 1
    10902-MM03-50
    10902-MM03-200
    10902-MM03-100
    50 µg 
    200 µg 
    100 µg 
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    Cyclin E1/CCNE1 cdna-clone 研究背景

    Cyclin E1 is a member of the highly conserved cyclin family and belongs to the E-type cyclin that functions as a regulator of S phase entry and progression in mammalian cells. Cyclin E1 serves as regulatory subunits that bind, activate, and provide substrate for its associated cyclin-dependent kinase2 (CDK2), whose activity is essential for cell cycle G1 / S transition. Over expression of this encoding gene has been found in many tumors, which results in chromosome instability and by extension, induce tumorigenesis. This protein was also found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. In general, cyclin E1, as an activator of phospho-CDK2 (pCDK2), is important for cell cycle progression and is frequently overexpressed in cancer cells.

     Cyclin E1/CCNE1 cdna-clone 参考资料
  • Honda R, et al. (2005) The structure of cyclin E1 / CDK2: implications for CDK2 activation and CDK2-independent roles. The EMBO Journal. 24: 452-63.
  • Geng Y, et al. (2007) Kinase-Independent Function of Cyclin E. 25(1): 127-39.
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