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人 TIGIT/VSTM3 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

产品数据评论实验方法
描述:   
表达宿主: Human Cells  
  • Slide 1
10917-H08H-50
10917-H08H-20
10917-H08H-10
50 µg 
20 µg 
10 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
50939-M08H-50
50939-M08H-100
50 µg 
100 µg 
Add to Cart
表达宿主: Human Cells  
  • Slide 1
50939-M02H-50
50939-M02H-100
50 µg 
100 µg 
Add to Cart
反应性: Mouse  
应用 : ELISA  IHC-P  
  • Slide 1
50939-T24-50
50939-T24-200
50939-T24-100
50 µg 
200 µg 
100 µg 
Add to Cart
反应性: Mouse  
应用 : ELISA  
    50939-RP01-400
    50939-RP01-200
    50939-RP01-100
    400 µg 
    200 µg 
    100 µg 
    Add to Cart

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    TIGIT/VSTM3 cdna-clone 研究背景

    TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed on regulatory, memory, activated T cells and NK cells. It binds PVR with high affinity, and PVRL2 with lower affinity, but not PVRL3. Knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses, however, TIGIT inhibits NK cytotoxicity directly through its ITIM. TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. The binding of PVR to TIGIT on human dendritic cells enhanced the production of IL-10 and diminished the production of IL-12p40. In addition, TIGIT counter inhibits the NK-mediated killing of tumor cells and protects normal cells from NK-mediated cytotoxicity thus providing an "alternative self" mechanism for MHC class I inhibition.

    Immune Checkpoint
    Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

     TIGIT/VSTM3 cdna-clone 参考资料
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