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人 TNFSF12 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

产品数据评论实验方法
表达宿主: Human Cells  
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50174-M01H-50
50174-M01H-20
50 µg 
20 µg 
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表达宿主: Human Cells  
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80154-R01H-50
80154-R01H-5
80154-R01H-20
50 µg 
5 µg 
20 µg 
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表达宿主: Human Cells  
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90094-C04H-50
90094-C04H-5
90094-C04H-20
50 µg 
5 µg 
20 µg 
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TNFSF12 cdna-clone 研究背景

TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. It is also found that TNFSF12 promotes proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. TNFSF12 also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

 TNFSF12 cdna-clone 参考资料
  • Wiley SR, et al. (2004) TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor. Cytokine Growth Factor Rev. 14(3-4):241-9.
  • Campbell S, et al. (2006) The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity. Front Biosci. 9:2273-84.
  • Lynch CN, et al. (1999) TWEAK induces angiogenesis and proliferation of endothelial cells. J Biol Chem. 274(13):8455-9.
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