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人 CD18/Integrin beta 2/ITGB2 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

产品数据评论实验方法

反应性: Human  
应用 : 
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102259-T10-50
102259-T10-200
102259-T10-100
50 µg 
200 µg 
100 µg 
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CD18/Integrin beta 2/ITGB2 cdna-clone 研究背景

Integrins form a family of heterodimeric transmembrane receptors that regulate cell–adhesion and cell-extracellular matrix interactions. Lymphocyte function-associated antigen 1 (LFA-1, αLβ2) is a leukocyte specific integrin that mediates firm arrest of leukocytes on the endothelium during migration and establishes cell-cell contacts such as the immunological synapse between DCs and T cells. At the molecular level, transient modifications of adhesion are accomplished by conformational changes of LFA-1 from a bent down inactive to an upright active conformation with an open headpiece, leading to low- and high-affinity for its major ligand ICAM-1 respectively.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

 CD18/Integrin beta 2/ITGB2 cdna-clone 参考资料
  • Eich C, Lasonder E, Cruz LJ, et al. Proteome Based Construction of the Lymphocyte Function-Associated Antigen 1 (LFA-1) Interactome in Human Dendritic Cells. Mattei F, ed. PLoS ONE. 2016;11(2):e0149637.
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