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人 IL6ST/gp130/CD130 基因ORF全长cDNA克隆(表达载体), N-Flag 标签

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表达宿主: Human Cells  
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10974-H02H-50
10974-H02H-10
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10 µg 
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描述: Active  
表达宿主: Human Cells  
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10974-H03H-20
10974-H03H-10
20 µg 
10 µg 
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表达宿主: Human Cells  
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10974-HCCH-200
10974-HCCH-100
200 µg 
100 µg 
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描述: Active  
表达宿主: CHO Cells  
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50135-M03C-200
50135-M03C-100
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100 µg 
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描述: Active  
表达宿主: Human Cells  
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50135-M08H-200
50135-M08H-100
200 µg 
100 µg 
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描述: Active  
表达宿主: Human Cells  
  • Slide 1
50135-M03H-200
50135-M03H-100
200 µg 
100 µg 
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描述: Active  
表达宿主: Human Cells  
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80030-R06H-50
80030-R06H-100
50 µg 
100 µg 
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描述: Active  
表达宿主: Human Cells  
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80030-R08H-50
80030-R08H-100
50 µg 
100 µg 
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表达宿主: Human Cells  
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90275-C02H-200
90275-C02H-100
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100 µg 
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表达宿主: Human Cells  
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90275-C08H-200
90275-C08H-100
200 µg 
100 µg 
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反应性: Human  
应用 : ELISA  
    10974-MM06-50
    10974-MM06-200
    10974-MM06-100
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    200 µg 
    100 µg 
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    反应性: Human  
    应用 : ELISA  
      10974-T16-50
      10974-T16-200
      10974-T16-100
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      200 µg 
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      反应性: Human  
      应用 : ELISA  
        10974-RP01-400
        10974-RP01-200
        10974-RP01-100
        400 µg 
        200 µg 
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        反应性: Human  
        应用 : 
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        101867-T10-50
        101867-T10-200
        101867-T10-100
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        反应性: Human  
        应用 : 
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        100126-R204-F-25
        100126-R204-F-100
        25 Test 
        100 Tests 
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        反应性: Human  
        应用 : 
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        100126-R204-50
        100126-R204-100
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        100 µg 
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        反应性: Mouse  
        应用 : 
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        50135-R022-P-25
        50135-R022-P-100
        25 Test 
        100 Tests 
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        反应性: Mouse  
        应用 : ELISA  
          50135-RP02-50
          50135-RP02-200
          50135-RP02-100
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          200 µg 
          100 µg 
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          反应性: Mouse  
          应用 : 
            50135-R001-50
            50135-R001-100
            50135-R001-1
            50 µg 
            100 µg 
            1 mg 
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            反应性: Mouse  
            应用 : IHC-P  
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            50135-R223-50
            50135-R223-100
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            反应性: Mouse  
            应用 : ELISA  
              50135-R230-50
              50135-R230-100
              50135-R230-1
              50 µg 
              100 µg 
              1 mg 
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              反应性: Mouse  
              应用 : 
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              50135-R022-50
              50135-R022-100
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              100 µg 
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              反应性: Mouse  
              应用 : ELISA  
                50135-RP01-200
                50135-RP01-100
                200 µg 
                100 µg 
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                反应性: Human  
                应用 : 
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                100126-R204-F-25
                100126-R204-F-100
                25 Test 
                100 Tests 
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                反应性: Human  
                应用 : 
                • Slide 1
                • Slide 1
                100126-R204-50
                100126-R204-100
                50 µg 
                100 µg 
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                反应性: Rat  
                应用 : FCM  
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                80030-R108-P-25
                80030-R108-P-100
                25 Test 
                100 Tests 
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                反应性: Rat  
                应用 : ELISA  
                  80030-R108-50
                  80030-R108-100
                  50 µg 
                  100 µg 
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                  反应性: Rat  
                  应用 : ELISA  
                    80030-T16-50
                    80030-T16-200
                    80030-T16-100
                    50 µg 
                    200 µg 
                    100 µg 
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                    反应性: Rat  
                    应用 : ELISA  
                      80030-RP01-400
                      80030-RP01-200
                      80030-RP01-100
                      400 µg 
                      200 µg 
                      100 µg 
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                      反应性: Rat  
                      应用 : ELISA  
                        80030-MM04-50
                        80030-MM04-200
                        80030-MM04-100
                        50 µg 
                        200 µg 
                        100 µg 
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                        反应性: Rhesus  
                        应用 : IHC-P  IF  ICC/IF  
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                        90275-T10-50
                        90275-T10-200
                        90275-T10-100
                        50 µg 
                        200 µg 
                        100 µg 
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                        IL6ST/gp130/CD130 cdna-clone 研究背景

                        Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.

                         IL6ST/gp130/CD130 cdna-clone 参考资料
                      • Hibi, et al. (1990) Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell. 63 (6): 1149-57.
                      • Kim H, et al. (1997) Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells. J Biol Chem. 272 (49): 30741-7.
                      • Giordano V, et al. (1997) Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase. J Immunol. 158 (9): 4097-103.
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